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SNX14 sorting nexin 14 [ Homo sapiens (human) ]

Gene ID: 57231, updated on 2-Nov-2024

Summary

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Official Symbol
SNX14provided by HGNC
Official Full Name
sorting nexin 14provided by HGNC
Primary source
HGNC:HGNC:14977
See related
Ensembl:ENSG00000135317 MIM:616105; AllianceGenome:HGNC:14977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCAR20; RGS-PX2
Summary
This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in testis (RPKM 30.0), thyroid (RPKM 16.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See SNX14 in Genome Data Viewer
Location:
6q14.3
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (85505496..85593858, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (86722300..86810666, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (86215214..86303576, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TPT1 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24787 Neighboring gene 5'-nucleotidase ecto Neighboring gene ReSE screen-validated silencer GRCh37_chr6:86210956-86211197 Neighboring gene Sharpr-MPRA regulatory region 13581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:86263391-86263890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:86262889-86263390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:86302067-86302652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:86302653-86303236 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:86303237-86303820 Neighboring gene synaptotagmin binding cytoplasmic RNA interacting protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17368 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17369 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17370 Neighboring gene pyruvate kinase M1/2 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNX14 inhibits autophagy via the PI3K/AKT/mTOR signaling cascade in breast cancer cells.
    Title: SNX14 inhibits autophagy via the PI3K/AKT/mTOR signaling cascade in breast cancer cells.
  2. The circSNX14 functions as a tumor suppressor via the miR-562/ LATS2 pathway in hepatocellular carcinoma cells.
    Title: The circSNX14 functions as a tumor suppressor via the miR-562/ LATS2 pathway in hepatocellular carcinoma cells.
  3. Snx14, an endoplasmic reticulum-resident protein associated with the cerebellar ataxia SCAR20, localizes to ER-LD contacts following fatty acid treatment, where it promotes lipid droplet maturation.
    Title: Cerebellar ataxia disease-associated Snx14 promotes lipid droplet growth at ER-droplet contacts.
  4. We therefore identify an important role for SNX14 in neutral lipid homeostasis between the endoplasmic reticulum , lysosomes and lipid droplets that may provide an early intervention target to alleviate the clinical symptoms of autosomal recessive cerebellar ataxia 20 (SCAR20).
    Title: SNX14 mutations affect endoplasmic reticulum-associated neutral lipid metabolism in autosomal recessive spinocerebellar ataxia 20.
  5. Here we report on a child with a novel missense mutation in the SNX14 gene that appears to be debilitating for protein conformation, function and review the previously reported cases from 15 families
    Title: Autosomal recessive spinocerebellar ataxia 20: Report of a new patient and review of literature.
  6. A unique ataxia syndrome due to biallelic SNX14 mutations leading to lysosome-autophagosome dysfunction.
    Title: Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction.
  7. SNX19 and SNX14 PX domains reveal key differences in spatial control of RGS-PX proteins in cell signaling and trafficking.
    Title: Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.
  8. Mutations in SNX14 cause a distinctive autosomal-recessive cerebellar ataxia and intellectual disability syndrome.
    Title: Mutations in SNX14 cause a distinctive autosomal-recessive cerebellar ataxia and intellectual disability syndrome.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Autosomal recessive spinocerebellar ataxia 20
MedGen: C5190595 OMIM: 616354 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC13217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sorting nexin-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047171.1 RefSeqGene

    Range
    5299..93661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297614.3 → NP_001284543.1  sorting nexin-14 isoform c

    See identical proteins and their annotated locations for NP_001284543.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment of the coding region compared to variant 1. It encodes a shorter isoform (c), compared to isoform a.
    Source sequence(s)
    BC005110, BC046520, CB054302, DA491624
    Consensus CDS
    CCDS75490.1
    UniProtKB/TrEMBL
    D6RJG9
    Related
    ENSP00000358641.2, ENST00000369627.6
    Conserved Domains (4) summary
    cd06877
    Location:555 → 677
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:340 → 466
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:130 → 299
    PXA; PXA domain
    pfam08628
    Location:798 → 902
    Nexin_C; Sorting nexin C terminal

  2. NM_001304479.2 → NP_001291408.1  sorting nexin-14 isoform d

    See identical proteins and their annotated locations for NP_001291408.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AK295417, CB054302
    Consensus CDS
    CCDS78163.1
    UniProtKB/TrEMBL
    D6RJG9
    Related
    ENSP00000427380.1, ENST00000505648.5
    Conserved Domains (4) summary
    cd06877
    Location:512 → 634
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:288 → 414
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:78 → 247
    PXA; PXA domain
    pfam08628
    Location:755 → 859
    Nexin_C; Sorting nexin C terminal

  3. NM_001350532.2 → NP_001337461.1  sorting nexin-14 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (e).
    Source sequence(s)
    AL136082, AL589666
    Consensus CDS
    CCDS93964.1
    UniProtKB/TrEMBL
    A0A804HKZ1, D6RJG9
    Related
    ENSP00000508127.1, ENST00000684570.1
    Conserved Domains (4) summary
    cd06877
    Location:585 → 707
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:361 → 487
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:151 → 320
    PXA; PXA domain
    pfam08628
    Location:828 → 932
    Nexin_C; Sorting nexin C terminal

  4. NM_001350533.2 → NP_001337462.1  sorting nexin-14 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Consensus CDS
    CCDS93960.1
    UniProtKB/TrEMBL
    A0A804HIK6, A0A804HKC6, D6RJG9
    Related
    ENSP00000507869.1, ENST00000682497.1
    Conserved Domains (4) summary
    cd06877
    Location:563 → 685
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:339 → 465
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:129 → 298
    PXA; PXA domain
    pfam08628
    Location:806 → 910
    Nexin_C; Sorting nexin C terminal

  5. NM_001350534.2 → NP_001337463.1  sorting nexin-14 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    UniProtKB/TrEMBL
    A0A804HIK6, D6RJG9
    Conserved Domains (4) summary
    cd06877
    Location:554 → 676
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:339 → 465
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:129 → 298
    PXA; PXA domain
    pfam08628
    Location:797 → 901
    Nexin_C; Sorting nexin C terminal

  6. NM_001350535.2 → NP_001337464.1  sorting nexin-14 isoform h

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Consensus CDS
    CCDS93959.1
    UniProtKB/TrEMBL
    A0A804HKJ3, D6RJG9
    Related
    ENSP00000507950.1, ENST00000684118.1
    Conserved Domains (4) summary
    cd06877
    Location:563 → 685
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:339 → 465
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:129 → 298
    PXA; PXA domain
    pfam08628
    Location:806 → 910
    Nexin_C; Sorting nexin C terminal

  7. NM_001350536.2 → NP_001337465.1  sorting nexin-14 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Consensus CDS
    CCDS93961.1
    UniProtKB/TrEMBL
    A0A804HI47, A0A804HJC6
    Related
    ENSP00000507444.1, ENST00000683643.1
    Conserved Domains (4) summary
    cd06877
    Location:520 → 642
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:296 → 422
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:137 → 255
    PXA; PXA domain
    pfam08628
    Location:763 → 867
    Nexin_C; Sorting nexin C terminal

  8. NM_001350537.2 → NP_001337466.1  sorting nexin-14 isoform j

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Consensus CDS
    CCDS93958.1
    UniProtKB/TrEMBL
    A0A804HI47, A0A804HIR3
    Related
    ENSP00000507188.1, ENST00000683785.1
    Conserved Domains (4) summary
    cd06877
    Location:519 → 641
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:295 → 421
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:136 → 254
    PXA; PXA domain
    pfam08628
    Location:762 → 866
    Nexin_C; Sorting nexin C terminal

  9. NM_001350538.2 → NP_001337467.1  sorting nexin-14 isoform k

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    UniProtKB/TrEMBL
    D6RJG9
    Conserved Domains (4) summary
    cd06877
    Location:516 → 638
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:292 → 418
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:130 → 251
    PXA; PXA domain
    pfam08628
    Location:759 → 863
    Nexin_C; Sorting nexin C terminal

  10. NM_001350539.2 → NP_001337468.1  sorting nexin-14 isoform l

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Consensus CDS
    CCDS93956.1
    UniProtKB/TrEMBL
    A0A804HIK6, A0A804HJ91, D6RJG9
    Related
    ENSP00000508327.1, ENST00000682171.1
    Conserved Domains (4) summary
    cd06877
    Location:511 → 633
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:287 → 413
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:77 → 246
    PXA; PXA domain
    pfam08628
    Location:754 → 858
    Nexin_C; Sorting nexin C terminal

  11. NM_001350540.2 → NP_001337469.1  sorting nexin-14 isoform m

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Consensus CDS
    CCDS93963.1
    UniProtKB/TrEMBL
    A0A804HJK3, A0A804HK55
    Related
    ENSP00000507777.1, ENST00000682682.1
    Conserved Domains (4) summary
    cd06877
    Location:564 → 686
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:340 → 466
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:130 → 299
    PXA; PXA domain
    pfam08628
    Location:778 → 856
    Nexin_C; Sorting nexin C terminal

  12. NM_001350541.2 → NP_001337470.1  sorting nexin-14 isoform n

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Consensus CDS
    CCDS93962.1
    UniProtKB/TrEMBL
    A0A804HJK3, A0A804HK22
    Related
    ENSP00000507742.1, ENST00000682738.1
    Conserved Domains (4) summary
    cd06877
    Location:555 → 677
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:340 → 466
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:130 → 299
    PXA; PXA domain
    pfam08628
    Location:769 → 847
    Nexin_C; Sorting nexin C terminal

  13. NM_001350542.2 → NP_001337471.1  sorting nexin-14 isoform o

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Consensus CDS
    CCDS93957.1
    UniProtKB/TrEMBL
    A0A804HI47, A0A804HIA1
    Related
    ENSP00000506970.1, ENST00000682491.1
    Conserved Domains (4) summary
    cd06877
    Location:468 → 590
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:244 → 370
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:85 → 203
    PXA; PXA domain
    pfam08628
    Location:711 → 815
    Nexin_C; Sorting nexin C terminal

  14. NM_001350543.2 → NP_001337472.1  sorting nexin-14 isoform p

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Consensus CDS
    CCDS93955.1
    UniProtKB/TrEMBL
    A0A804HI30, A0A804HIK6, D6RJG9
    Related
    ENSP00000506873.1, ENST00000684647.1
    Conserved Domains (4) summary
    cd06877
    Location:467 → 589
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:243 → 369
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:84 → 202
    PXA; PXA domain
    pfam08628
    Location:710 → 814
    Nexin_C; Sorting nexin C terminal

  15. NM_001350544.2 → NP_001337473.1  sorting nexin-14 isoform q

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    UniProtKB/TrEMBL
    D6RJG9
    Conserved Domains (4) summary
    cd06877
    Location:464 → 586
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:240 → 366
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:78 → 199
    PXA; PXA domain
    pfam08628
    Location:707 → 811
    Nexin_C; Sorting nexin C terminal

  16. NM_001350545.2 → NP_001337474.1  sorting nexin-14 isoform r

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 19, encodes isoform r.
    Source sequence(s)
    AL136082, AL589666
    UniProtKB/TrEMBL
    A0A804HI51
    Conserved Domains (4) summary
    cd06877
    Location:416 → 538
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:192 → 318
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:6 → 151
    PXA; PXA domain
    pfam08628
    Location:659 → 763
    Nexin_C; Sorting nexin C terminal

  17. NM_001350546.2 → NP_001337475.1  sorting nexin-14 isoform r

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variant 18, encodes isoform r.
    Source sequence(s)
    AL136082, AL589666
    UniProtKB/TrEMBL
    A0A804HI51
    Conserved Domains (4) summary
    cd06877
    Location:416 → 538
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:192 → 318
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:6 → 151
    PXA; PXA domain
    pfam08628
    Location:659 → 763
    Nexin_C; Sorting nexin C terminal

  18. NM_001350547.2 → NP_001337476.1  sorting nexin-14 isoform s

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Conserved Domains (3) summary
    cd06877
    Location:214 → 336
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:1 → 116
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam08628
    Location:457 → 561
    Nexin_C; Sorting nexin C terminal

  19. NM_001350548.2 → NP_001337477.1  sorting nexin-14 isoform t

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 22-25, encodes isoform t.
    Source sequence(s)
    AL136082, AL589666
    Conserved Domains (3) summary
    cd06877
    Location:179 → 301
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    pfam08628
    Location:422 → 526
    Nexin_C; Sorting nexin C terminal
    cl02565
    Location:1 → 81
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  20. NM_001350549.2 → NP_001337478.1  sorting nexin-14 isoform t

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 21 and 23-25, encodes isoform t.
    Source sequence(s)
    AL136082, AL589666
    Conserved Domains (3) summary
    cd06877
    Location:179 → 301
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    pfam08628
    Location:422 → 526
    Nexin_C; Sorting nexin C terminal
    cl02565
    Location:1 → 81
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  21. NM_001350550.2 → NP_001337479.1  sorting nexin-14 isoform t

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 21, 22, 24, and 25, encodes isoform t.
    Source sequence(s)
    AL136082, AL589666
    Conserved Domains (3) summary
    cd06877
    Location:179 → 301
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    pfam08628
    Location:422 → 526
    Nexin_C; Sorting nexin C terminal
    cl02565
    Location:1 → 81
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  22. NM_001350551.2 → NP_001337480.1  sorting nexin-14 isoform t

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 21-23 and 25, encodes isoform t.
    Source sequence(s)
    AL136082, AL589666
    Conserved Domains (3) summary
    cd06877
    Location:179 → 301
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    pfam08628
    Location:422 → 526
    Nexin_C; Sorting nexin C terminal
    cl02565
    Location:1 → 81
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  23. NM_001350552.2 → NP_001337481.1  sorting nexin-14 isoform t

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 21-24, encodes isoform t.
    Source sequence(s)
    AL136082, AL589666
    Conserved Domains (3) summary
    cd06877
    Location:179 → 301
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    pfam08628
    Location:422 → 526
    Nexin_C; Sorting nexin C terminal
    cl02565
    Location:1 → 81
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  24. NM_001350553.2 → NP_001337482.1  sorting nexin-14 isoform u

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Conserved Domains (3) summary
    cd06877
    Location:170 → 292
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    pfam08628
    Location:413 → 517
    Nexin_C; Sorting nexin C terminal
    cl02565
    Location:1 → 81
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  25. NM_020468.6 → NP_065201.1  sorting nexin-14 isoform b

    See identical proteins and their annotated locations for NP_065201.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks in-frame segments of the coding region compared to variant 1. It encodes a shorter isoform (b), compared to isoform a.
    Source sequence(s)
    BC005110, CB054302
    Consensus CDS
    CCDS5003.1
    UniProtKB/TrEMBL
    A0A804HI47
    Related
    ENSP00000257769.3, ENST00000346348.7
    Conserved Domains (4) summary
    cd06877
    Location:511 → 633
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:296 → 422
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:137 → 255
    PXA; PXA domain
    pfam08628
    Location:754 → 858
    Nexin_C; Sorting nexin C terminal

  26. NM_153816.6 → NP_722523.1  sorting nexin-14 isoform a

    See identical proteins and their annotated locations for NP_722523.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    BC005110, BC095419, CB054302, DA491624
    Consensus CDS
    CCDS5004.1
    UniProtKB/Swiss-Prot
    B4DI55, Q4VBR3, Q5TCF9, Q5TCG0, Q6NUI7, Q6PI37, Q9BSD1, Q9Y5W7
    UniProtKB/TrEMBL
    D6RJG9
    Related
    ENSP00000313121.3, ENST00000314673.8
    Conserved Domains (4) summary
    cd06877
    Location:564 → 686
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:340 → 466
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:130 → 299
    PXA; PXA domain
    pfam08628
    Location:807 → 911
    Nexin_C; Sorting nexin C terminal

RNA

  1. NR_146774.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Related
    ENST00000682633.1

  2. NR_146775.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Related
    ENST00000684299.1

  3. NR_146776.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Related
    ENST00000683577.1

  4. NR_146777.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Related
    ENST00000682688.1

  5. NR_146778.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Related
    ENST00000684319.1

  6. NR_146779.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136082, AL589666
    Related
    ENST00000682133.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    85505496..85593858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419128.1 → XP_047275084.1  sorting nexin-14 isoform X10

  2. XM_047419127.1 → XP_047275083.1  sorting nexin-14 isoform X9

  3. XM_047419123.1 → XP_047275079.1  sorting nexin-14 isoform X5

    Related
    ENSP00000507491.1, ENST00000684680.1

  4. XM_047419121.1 → XP_047275077.1  sorting nexin-14 isoform X4

  5. XM_047419120.1 → XP_047275076.1  sorting nexin-14 isoform X2

  6. XM_047419129.1 → XP_047275085.1  sorting nexin-14 isoform X10

  7. XM_047419124.1 → XP_047275080.1  sorting nexin-14 isoform X6

  8. XM_017011090.2 → XP_016866579.1  sorting nexin-14 isoform X3

    UniProtKB/TrEMBL
    A0A804HIK6, A0A804HJ91, D6RJG9
    Related
    ENSP00000507401.1, ENST00000684150.1
    Conserved Domains (4) summary
    cd06877
    Location:511 → 633
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:287 → 413
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:77 → 246
    PXA; PXA domain
    pfam08628
    Location:754 → 858
    Nexin_C; Sorting nexin C terminal

  9. XM_047419126.1 → XP_047275082.1  sorting nexin-14 isoform X8

    UniProtKB/TrEMBL
    A0A804HIA1

  10. XM_047419122.1 → XP_047275078.1  sorting nexin-14 isoform X5

  11. XM_047419125.1 → XP_047275081.1  sorting nexin-14 isoform X7

    Related
    ENSP00000507625.1, ENST00000682464.1

  12. XM_011535977.3 → XP_011534279.2  sorting nexin-14 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    86722300..86810666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356027.1 → XP_054212002.1  sorting nexin-14 isoform X10

  2. XM_054356026.1 → XP_054212001.1  sorting nexin-14 isoform X9

  3. XM_054356022.1 → XP_054211997.1  sorting nexin-14 isoform X5

  4. XM_054356020.1 → XP_054211995.1  sorting nexin-14 isoform X4

  5. XM_054356018.1 → XP_054211993.1  sorting nexin-14 isoform X2

  6. XM_054356028.1 → XP_054212003.1  sorting nexin-14 isoform X10

  7. XM_054356023.1 → XP_054211998.1  sorting nexin-14 isoform X6

  8. XM_054356019.1 → XP_054211994.1  sorting nexin-14 isoform X3

  9. XM_054356025.1 → XP_054212000.1  sorting nexin-14 isoform X8

  10. XM_054356021.1 → XP_054211996.1  sorting nexin-14 isoform X5

  11. XM_054356024.1 → XP_054211999.1  sorting nexin-14 isoform X7

  12. XM_054356017.1 → XP_054211992.1  sorting nexin-14 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5W7.3 GenPept UniProtKB/Swiss-Prot:Q9Y5W7

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