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SLC45A4 solute carrier family 45 member 4 [ Homo sapiens (human) ]

Gene ID: 57210, updated on 10-Oct-2024

Summary

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Official Symbol
SLC45A4provided by HGNC
Official Full Name
solute carrier family 45 member 4provided by HGNC
Primary source
HGNC:HGNC:29196
See related
Ensembl:ENSG00000022567 MIM:619581; AllianceGenome:HGNC:29196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable sucrose:proton symporter activity. Predicted to be involved in sucrose transport. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 5.0), stomach (RPKM 3.0) and 24 other tissues See more
Orthologs
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Genomic context

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See SLC45A4 in Genome Data Viewer
Location:
8q24.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (141207174..141308288, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (142328543..142429759, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142217273..142318387, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142138949-142139779 Neighboring gene DENND3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142144757-142145375 Neighboring gene DENN domain containing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142163840-142164798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142167099-142167874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28046 Neighboring gene Sharpr-MPRA regulatory region 5779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142183015-142183516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142183517-142184016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142191187-142191687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142194501-142195455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142202224-142202724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142202725-142203225 Neighboring gene uncharacterized LOC105375785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142218415-142218922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142218923-142219430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142229255-142229790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142231827-142232566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142232567-142233305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142237903-142238756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142239613-142240468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142240469-142241324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142248324-142248883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142248884-142249442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142250482-142251464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142256416-142257096 Neighboring gene SLC45A4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142268351-142268872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142280921-142281591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142281592-142282261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142286540-142287116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142288141-142288950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142291898-142292707 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:142293955-142294169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142299831-142300486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142309143-142309849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142309892-142310741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142310742-142311590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19591 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142334125-142334625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142339206-142339742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142339743-142340277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142345611-142346110 Neighboring gene Sharpr-MPRA regulatory region 12881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142352272-142352772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142355946-142356566 Neighboring gene long intergenic non-protein coding RNA 1300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142361861-142362840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142366583-142367204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142367205-142367826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142369677-142370273 Neighboring gene G protein-coupled receptor 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SLC45A4 promotes glycolysis and prevents AMPK/ULK1-induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma. Chen W, et al. J Gene Med, 2021 Sep. PMID 34010493, Free PMC Article
  2. Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae. Bartölke R, et al. Biochem J, 2014 Dec 1. PMID 25164149
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. Hirosawa M, et al. DNA Res, 1999 Oct 29. PMID 10574461
  4. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Psychiatric GWAS Consortium Bipolar Disorder Working Group. Nat Genet, 2011 Sep 18. PMID 21926972, Free PMC Article
  5. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Slc45a4 Gene Regulates Pigmentation in a Manner Distinct from that of the OCA4 Gene Slc45a2.
    Title: The Slc45a4 Gene Regulates Pigmentation in a Manner Distinct from that of the OCA4 Gene Slc45a2.
  2. SLC45A4 promotes glycolysis and prevents AMPK/ULK1-induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma.
    Title: SLC45A4 promotes glycolysis and prevents AMPK/ULK1-induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sucrose:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sucrose:proton symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in sucrose transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 45 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080431.3 → NP_001073900.1  solute carrier family 45 member 4 isoform 2

    See identical proteins and their annotated locations for NP_001073900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses an alternate start codon compared to variant 1. This variant (2) also uses an alternate splice site in the 3' coding region which results in a frame shift. The encoded isoform (2) is shorter and has a distinct N- and C- termini compared to isoform 1.
    Source sequence(s)
    AC011676, AI769055, AK128212
    Consensus CDS
    CCDS34948.1
    UniProtKB/TrEMBL
    B2RXG1
    Related
    ENSP00000024061.3, ENST00000024061.7
    Conserved Domains (1) summary
    cd06174
    Location:24 → 200
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. NM_001286646.2 → NP_001273575.1  solute carrier family 45 member 4 isoform 1

    See identical proteins and their annotated locations for NP_001273575.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC011676
    Consensus CDS
    CCDS75795.1
    UniProtKB/TrEMBL
    B2RXG1, E7EV90
    Related
    ENSP00000428137.1, ENST00000517878.6
    Conserved Domains (1) summary
    cl28910
    Location:52 → 270
    MFS; Major Facilitator Superfamily

  3. NM_001286648.2 → NP_001273577.1  solute carrier family 45 member 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate start codon compared to variant 1. This variant (2) also uses an alternate splice site in the 3' coding region which results in a frame shift. The encoded isoform (3) is shorter and has a distinct N- and C- termini compared to isoform 1
    Source sequence(s)
    AK128212, BC090891
    Consensus CDS
    CCDS69550.1
    UniProtKB/TrEMBL
    B2RXG1
    Related
    ENSP00000429059.1, ENST00000519067.5
    Conserved Domains (1) summary
    cd06174
    Location:24 → 200
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    141207174..141308288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517179.3 → XP_011515481.1  solute carrier family 45 member 4 isoform X13

    UniProtKB/TrEMBL
    B2RXG1
    Conserved Domains (1) summary
    cd06174
    Location:325 → 521
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. XM_011517171.3 → XP_011515473.1  solute carrier family 45 member 4 isoform X2

    See identical proteins and their annotated locations for XP_011515473.1

    UniProtKB/TrEMBL
    B2RXG1, E7EV90
    Conserved Domains (1) summary
    cl28910
    Location:52 → 270
    MFS; Major Facilitator Superfamily

  3. XM_047422002.1 → XP_047277958.1  solute carrier family 45 member 4 isoform X3

  4. XM_047422001.1 → XP_047277957.1  solute carrier family 45 member 4 isoform X2

    UniProtKB/TrEMBL
    E7EV90

  5. XM_047422014.1 → XP_047277970.1  solute carrier family 45 member 4 isoform X13

  6. XM_011517174.3 → XP_011515476.1  solute carrier family 45 member 4 isoform X10

    UniProtKB/TrEMBL
    B2RXG1
    Conserved Domains (1) summary
    cd06174
    Location:24 → 200
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  7. XM_047422015.1 → XP_047277971.1  solute carrier family 45 member 4 isoform X14

  8. XM_047422011.1 → XP_047277967.1  solute carrier family 45 member 4 isoform X11

  9. XM_011517173.3 → XP_011515475.2  solute carrier family 45 member 4 isoform X1

  10. XM_047421999.1 → XP_047277955.1  solute carrier family 45 member 4 isoform X1

  11. XM_047422012.1 → XP_047277968.1  solute carrier family 45 member 4 isoform X11

  12. XM_047422009.1 → XP_047277965.1  solute carrier family 45 member 4 isoform X9

    UniProtKB/Swiss-Prot
    Q5BKX6, Q6ZRI2, Q9ULU3

  13. XM_047421998.1 → XP_047277954.1  solute carrier family 45 member 4 isoform X1

  14. XM_047421997.1 → XP_047277953.1  solute carrier family 45 member 4 isoform X1

  15. XM_047422004.1 → XP_047277960.1  solute carrier family 45 member 4 isoform X5

  16. XM_047422005.1 → XP_047277961.1  solute carrier family 45 member 4 isoform X6

  17. XM_047422008.1 → XP_047277964.1  solute carrier family 45 member 4 isoform X9

    UniProtKB/Swiss-Prot
    Q5BKX6, Q6ZRI2, Q9ULU3

  18. XM_047422010.1 → XP_047277966.1  solute carrier family 45 member 4 isoform X9

    UniProtKB/Swiss-Prot
    Q5BKX6, Q6ZRI2, Q9ULU3

  19. XM_047422000.1 → XP_047277956.1  solute carrier family 45 member 4 isoform X1

  20. XM_047422013.1 → XP_047277969.1  solute carrier family 45 member 4 isoform X11

  21. XM_011517172.3 → XP_011515474.2  solute carrier family 45 member 4 isoform X9

    UniProtKB/Swiss-Prot
    Q5BKX6, Q6ZRI2, Q9ULU3

  22. XM_047422007.1 → XP_047277963.1  solute carrier family 45 member 4 isoform X8

  23. XM_011517177.3 → XP_011515479.2  solute carrier family 45 member 4 isoform X12

  24. XM_047422006.1 → XP_047277962.1  solute carrier family 45 member 4 isoform X7

  25. XM_047422003.1 → XP_047277959.1  solute carrier family 45 member 4 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    142328543..142429759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360881.1 → XP_054216856.1  solute carrier family 45 member 4 isoform X13

  2. XM_054360865.1 → XP_054216840.1  solute carrier family 45 member 4 isoform X2

  3. XM_054360866.1 → XP_054216841.1  solute carrier family 45 member 4 isoform X3

  4. XM_054360864.1 → XP_054216839.1  solute carrier family 45 member 4 isoform X2

  5. XM_054360876.1 → XP_054216851.1  solute carrier family 45 member 4 isoform X10

  6. XM_054360882.1 → XP_054216857.1  solute carrier family 45 member 4 isoform X14

  7. XM_054360877.1 → XP_054216852.1  solute carrier family 45 member 4 isoform X11

  8. XM_054360859.1 → XP_054216834.1  solute carrier family 45 member 4 isoform X1

  9. XM_054360862.1 → XP_054216837.1  solute carrier family 45 member 4 isoform X1

  10. XM_054360860.1 → XP_054216835.1  solute carrier family 45 member 4 isoform X1

  11. XM_054360873.1 → XP_054216848.1  solute carrier family 45 member 4 isoform X9

  12. XM_054360878.1 → XP_054216853.1  solute carrier family 45 member 4 isoform X11

  13. XM_054360861.1 → XP_054216836.1  solute carrier family 45 member 4 isoform X1

  14. XM_054360868.1 → XP_054216843.1  solute carrier family 45 member 4 isoform X5

  15. XM_054360869.1 → XP_054216844.1  solute carrier family 45 member 4 isoform X6

  16. XM_054360858.1 → XP_054216833.1  solute carrier family 45 member 4 isoform X1

  17. XM_054360872.1 → XP_054216847.1  solute carrier family 45 member 4 isoform X9

  18. XM_054360875.1 → XP_054216850.1  solute carrier family 45 member 4 isoform X9

  19. XM_054360863.1 → XP_054216838.1  solute carrier family 45 member 4 isoform X1

  20. XM_054360879.1 → XP_054216854.1  solute carrier family 45 member 4 isoform X11

  21. XM_054360874.1 → XP_054216849.1  solute carrier family 45 member 4 isoform X9

  22. XM_054360871.1 → XP_054216846.1  solute carrier family 45 member 4 isoform X8

  23. XM_054360880.1 → XP_054216855.1  solute carrier family 45 member 4 isoform X12

  24. XM_054360870.1 → XP_054216845.1  solute carrier family 45 member 4 isoform X7

  25. XM_054360867.1 → XP_054216842.1  solute carrier family 45 member 4 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BKX6.2 GenPept UniProtKB/Swiss-Prot:Q5BKX6

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