zgc:162025 zgc:162025 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: zgc:162025provided by ZNC
Official Full Name: zgc:162025provided by ZNC
Primary source: ZFIN:ZDB-GENE-070424-17
See related: Ensembl:ENSDARG00000046141 AllianceGenome:ZFIN:ZDB-GENE-070424-17
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:103536; si:dkey-117k10.4
Summary: Involved in Spemann organizer formation and negative regulation of Wnt signaling pathway. Acts upstream of or within anterior head development. Predicted to be located in nuclear envelope. Orthologous to human C12orf43 (chromosome 12 open reading frame 43). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

See zgc:162025 in Genome Data Viewer

Location:: chromosome: 8

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (39816492..39822917, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (39782725..39789055, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Custos binds to beta-catenin in a Wnt responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
Title: Custos controls β-catenin to regulate head development during vertebrate embryogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in Spemann organizer formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Spemann organizer formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior head development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein CUSTOS

Names: Custos; uncharacterized protein C12orf43 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.