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abl2 c-abl oncogene 2, non-receptor tyrosine kinase [ Danio rerio (zebrafish) ]

Gene ID: 570636, updated on 18-Sep-2024

Summary

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Official Symbol
abl2provided by ZNC
Official Full Name
c-abl oncogene 2, non-receptor tyrosine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020809-2
See related
Ensembl:ENSDARG00000013841 AllianceGenome:ZFIN:ZDB-GENE-020809-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb272
Summary
Predicted to enable protein tyrosine kinase activity. Predicted to act upstream of or within protein phosphorylation. Is expressed in adaxial cell; myotome; and somite. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See abl2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (14914886..14982143)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (14877149..14944813)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-21p1.3 Neighboring gene sterol O-acyltransferase 1 Neighboring gene formin binding protein 1-like Neighboring gene BCAR3 adaptor protein, NSP family member

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article
  2. An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. Postlethwait JH, et al. bioRxiv, 2020 Sep 2. PMID 32908984, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cellular component organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase ABL2
Names
v-abl Abelson murine leukemia viral oncogene homolog 2
NP_001116177.1
XP_005166946.1
XP_005166947.1
XP_005166948.1
XP_017212852.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122705.1 → NP_001116177.1  tyrosine-protein kinase ABL2

    Status: PROVISIONAL

    Source sequence(s)
    CR381644, CR450721
    UniProtKB/TrEMBL
    A0A8M1NI86, B0UXN7
    Related
    ENSDARP00000041696.7, ENSDART00000041697.8
    Conserved Domains (5) summary
    smart00808
    Location:1010 → 1135
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:127 → 220
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:69 → 122
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:239 → 501
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:246 → 497
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    14914886..14982143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166889.5 → XP_005166946.1  tyrosine-protein kinase ABL2 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IYB8, A0A8M2BEE2
    Related
    ENSDARP00000140170.1, ENSDART00000164385.3
    Conserved Domains (5) summary
    smart00808
    Location:1057 → 1182
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:174 → 267
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:116 → 169
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:286 → 548
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:293 → 544
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_005166890.5 → XP_005166947.1  tyrosine-protein kinase ABL2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BE86
    Conserved Domains (5) summary
    smart00808
    Location:1056 → 1181
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:173 → 266
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:115 → 168
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:285 → 547
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:292 → 543
    Pkinase_Tyr; Protein tyrosine kinase

  3. XM_017357363.3 → XP_017212852.1  tyrosine-protein kinase ABL2 isoform X4

    UniProtKB/TrEMBL
    A0A8M6Z7N2

  4. XM_005166891.5 → XP_005166948.1  tyrosine-protein kinase ABL2 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BEX3
    Conserved Domains (5) summary
    smart00808
    Location:1009 → 1134
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:126 → 219
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:68 → 121
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:238 → 500
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:245 → 496
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein
Heading Accession and Version

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