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stab1 stabilin 1 [ Danio rerio (zebrafish) ]

Gene ID: 570626, updated on 2-Nov-2024

Summary

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Official Symbol
stab1provided by ZNC
Official Full Name
stabilin 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-554
See related
Ensembl:ENSDARG00000076484 AllianceGenome:ZFIN:ZDB-GENE-050208-554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
FEEL-1; stab1l; si:dkeyp-87e7.6
Summary
Enables scavenger receptor activity. Acts upstream of or within several processes, including cholesterol homeostasis; low-density lipoprotein particle clearance; and oxidised low-density lipoprotein particle clearance. Predicted to be located in membrane. Is expressed in several structures, including axis; caudal hematopoietic tissue; pharynx; post-vent region; and vasculature. Orthologous to human STAB1 (stabilin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See stab1 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
69
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10281789..10353942, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10252355..10324736, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 6a Neighboring gene coiled-coil domain containing 71 Neighboring gene uncharacterized LOC108181206 Neighboring gene nischarin Neighboring gene wu:fb55g09

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles. Arias-Alpizar G, et al. Nanomedicine, 2021 Jun. PMID 33838334
  2. HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2. Stoll SJ, et al. PLoS One, 2013. PMID 23484014, Free PMC Article
  3. Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake. Campbell F, et al. ACS Nano, 2018 Mar 27. PMID 29320626, Free PMC Article
  4. ETS factors are required but not sufficient for specific patterns of enhancer activity in different endothelial subtypes. Neal A, et al. Dev Biol, 2021 May. PMID 33453264, Free PMC Article
  5. Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish. Verwilligen RAF, et al. Atherosclerosis, 2022 Apr. PMID 35247629

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables scavenger receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables scavenger receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cholesterol homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within low-density lipoprotein particle clearance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within oxidised low-density lipoprotein particle clearance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis involved in cholesterol transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis involved in cholesterol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
stabilin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195614.2 → NP_001182543.1  stabilin-1 precursor

    See identical proteins and their annotated locations for NP_001182543.1

    Status: VALIDATED

    Source sequence(s)
    BX649457, BX908725
    UniProtKB/TrEMBL
    A0A8M1NXC8, E0CZJ3
    Related
    ENSDARP00000086483.4, ENSDART00000092050.6
    Conserved Domains (5) summary
    COG2335
    Location:455 → 630
    FAS1; Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only]
    cd03515
    Location:2198 → 2290
    Link_domain_TSG_6_like; This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ...
    pfam02469
    Location:1611 → 1711
    Fasciclin; Fasciclin domain
    pfam12947
    Location:1458 → 1494
    EGF_3; EGF domain
    cl02663
    Location:2322 → 2448
    Fasciclin; Fasciclin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    10281789..10353942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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