U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cfap251 cilia and flagella associated protein 251 [ Danio rerio (zebrafish) ]

Gene ID: 569257, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
cfap251provided by ZNC
Official Full Name
cilia and flagella associated protein 251provided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-328
See related
Ensembl:ENSDARG00000059855 AllianceGenome:ZFIN:ZDB-GENE-060526-328
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wdr66; si:dkey-65b12.4
Summary
Acts upstream of or within neutrophil differentiation and thrombocyte differentiation. Predicted to be located in motile cilium. Predicted to be active in sperm flagellum. Human ortholog(s) of this gene implicated in spermatogenic failure 33. Orthologous to human CFAP251 (cilia and flagella associated protein 251). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cfap251 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (41774143..41792843)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (41174054..41192690)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108190180 Neighboring gene uncharacterized LOC100334916 Neighboring gene BAF chromatin remodeling complex subunit BCL7A Neighboring gene alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Neighboring gene si:dkey-65b12.6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. Bielczyk-Maczyńska E, et al. PLoS Genet, 2014 Jul. PMID 25010335, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thrombocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
WD repeat-containing protein 66; cilia- and flagella-associated protein 251
Names
WD repeat domain 66

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    41774143..41792843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476572.2 → XP_021332247.1  cilia- and flagella-associated protein 251

    UniProtKB/TrEMBL
    A0A8M9PLA2, F1Q8Y1
    Related
    ENSDARP00000078100.5, ENSDART00000083665.6
    Conserved Domains (4) summary
    COG2319
    Location:62 → 537
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:278 → 319
    7WD40; WD40 repeat [structural motif]
    cl25352
    Location:772 → 919
    EFh_PEF; The penta-EF hand (PEF) family
    cl25539
    Location:420 → 734
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_068221476.1 → XP_068077577.1  cilia- and flagella-associated protein 251

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394603.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    19854..38537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471668.2 → XP_021327343.1  cilia- and flagella-associated protein 251

    UniProtKB/TrEMBL
    A0A2R8RY46, A0A8M9PK40
    Conserved Domains (4) summary
    COG2319
    Location:62 → 537
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:470 → 511
    7WD40; WD40 repeat [structural motif]
    cl25352
    Location:772 → 919
    EFh_PEF; The penta-EF hand (PEF) family
    cl25539
    Location:420 → 734
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_068218255.1 → XP_068074356.1  cilia- and flagella-associated protein 251

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools