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dlg5a discs, large homolog 5a (Drosophila) [ Danio rerio (zebrafish) ]

Gene ID: 569065, updated on 2-Nov-2024

Summary

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Official Symbol
dlg5aprovided by ZNC
Official Full Name
discs, large homolog 5a (Drosophila)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3149
See related
Ensembl:ENSDARG00000074059 AllianceGenome:ZFIN:ZDB-GENE-030131-3149
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dlg5; wu:fc28f03
Summary
Predicted to be involved in negative regulation of hippo signaling. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be located in membrane. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dlg5a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (16342486..16497065)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (16210938..16366073)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene annexin A11a Neighboring gene molybdenum cofactor sulfurase Neighboring gene potassium large conductance calcium-activated channel, subfamily M, alpha member 1a Neighboring gene uncharacterized LOC137487382 Neighboring gene leucine rich melanocyte differentiation associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cytoskeletal Keratins Are Overexpressed in a Zebrafish Model of Idiopathic Scoliosis. Cuevas M, et al. Genes (Basel), 2023 May 9. PMID 37239418, Free PMC Article
  2. Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish. Terhune EA, et al. Hum Mutat, 2021 Apr. PMID 33382518, Free PMC Article
  3. A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons. Gordon PM, et al. Nat Commun, 2021 Mar 26. PMID 33771997, Free PMC Article
  4. Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. Tsai HY, et al. BMC Genomics, 2015 Nov 18. PMID 26582102, Free PMC Article
  5. Statistical evidence for a more than 800-million-year-old evolutionarily conserved genomic region in our genome. Danchin EG, et al. J Mol Evol, 2004 Nov. PMID 15693615

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in negative regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
disks large homolog 5a
Names
discs, large homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145603.1 → NP_001139075.1  disks large homolog 5a

    Status: PROVISIONAL

    Source sequence(s)
    AL645926, BX323467, BX323798
    UniProtKB/TrEMBL
    A0A8M1NT87, B7ZC95
    Related
    ENSDARP00000096269.4, ENSDART00000105496.5
    Conserved Domains (11) summary
    cd11860
    Location:1604 → 1666
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00228
    Location:1346 → 1428
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:673 → 760
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01671
    Location:9 → 88
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    pfam00625
    Location:1745 → 1914
    Guanylate_kin; Guanylate kinase
    pfam04822
    Location:105 → 188
    Takusan; Takusan
    pfam05276
    Location:421 → 625
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
    pfam09728
    Location:272 → 604
    Taxilin; Myosin-like coiled-coil protein
    pfam16610
    Location:1426 → 1506
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl17190
    Location:1759 → 1915
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    cl23720
    Location:315 → 437
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    16342486..16497065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068212911.1 → XP_068069012.1  disks large homolog 5a isoform X2

  2. XM_068212910.1 → XP_068069011.1  disks large homolog 5a isoform X1

  3. XM_005156681.5 → XP_005156738.1  disks large homolog 5a isoform X4

    UniProtKB/TrEMBL
    A0A8M2B3K9
    Related
    ENSDARP00000111982.1, ENSDART00000124710.4
    Conserved Domains (11) summary
    cd11860
    Location:1639 → 1701
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00228
    Location:1381 → 1463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:696 → 783
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01671
    Location:9 → 88
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    pfam00625
    Location:1780 → 1949
    Guanylate_kin; Guanylate kinase
    pfam04822
    Location:128 → 211
    Takusan; Takusan
    pfam05276
    Location:444 → 648
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
    pfam09728
    Location:295 → 627
    Taxilin; Myosin-like coiled-coil protein
    pfam16610
    Location:1461 → 1541
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl17190
    Location:1794 → 1950
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    cl23720
    Location:338 → 460
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  4. XM_068212912.1 → XP_068069013.1  disks large homolog 5a isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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