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plce1 phospholipase C, epsilon 1 [ Danio rerio (zebrafish) ]

Gene ID: 568288, updated on 14-Nov-2024

Summary

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Official Symbol
plce1provided by ZNC
Official Full Name
phospholipase C, epsilon 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-061212-4
See related
Ensembl:ENSDARG00000087921 AllianceGenome:ZFIN:ZDB-GENE-061212-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable phosphatidylinositol phospholipase C activity. Acts upstream of or within glomerular basement membrane development. Is expressed in several structures, including brain; digestive system; muscle; notochord; and pronephric glomerulus. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See plce1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (5240483..5399690)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (5205522..5363945)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene leucine-rich, glioma inactivated 1b Neighboring gene solute carrier family 35 member G1 Neighboring gene NOC3-like DNA replication regulator Neighboring gene TBC1 domain family, member 12b Neighboring gene dopamine receptor D6b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression of phospholipase C epsilon 1 in zebrafish. Zhou W, et al. Gene Expr Patterns, 2009 Jun. PMID 19332147
  2. Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Hinkes B, et al. Nat Genet, 2006 Dec. PMID 17086182
  3. Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis. Djenoune L, et al. J Am Soc Nephrol, 2021 Jul. PMID 33911000, Free PMC Article
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glomerular basement membrane development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glomerulus development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
NP_001155125.1
XP_021335822.1
XP_021335823.1
XP_021335824.1
XP_021335825.1
XP_021335826.1
XP_021335827.1
XP_021335828.1
XP_021335829.1
XP_068080741.1
XP_068080742.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161653.1 → NP_001155125.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

    See identical proteins and their annotated locations for NP_001155125.1

    Status: PROVISIONAL

    Source sequence(s)
    EU919685
    UniProtKB/TrEMBL
    C5H807
    Related
    ENSDARP00000112202.2, ENSDART00000124097.3
    Conserved Domains (6) summary
    cd00275
    Location:1831 → 1946
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:2092 → 2191
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1359 → 1796
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02222
    Location:1292 → 1933
    PLN02222; phosphoinositide phospholipase C 2
    pfam00617
    Location:483 → 668
    RasGEF; RasGEF domain
    pfam09279
    Location:1292 → 1347
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    5240483..5399690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480151.2 → XP_021335826.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

    UniProtKB/TrEMBL
    A0A8M9QIU6
    Conserved Domains (5) summary
    cd01780
    Location:2106 → 2205
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1359 → 1810
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    pfam00617
    Location:483 → 668
    RasGEF; RasGEF domain
    cd16203
    Location:1166 → 1346
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cl27705
    Location:1355 → 1960
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  2. XM_068224640.1 → XP_068080741.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6

  3. XM_021480152.2 → XP_021335827.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X7

    UniProtKB/TrEMBL
    A0A8M9PWH5
    Conserved Domains (5) summary
    cd01780
    Location:2092 → 2191
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1359 → 1796
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    pfam00617
    Location:483 → 668
    RasGEF; RasGEF domain
    cd16203
    Location:1166 → 1346
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cl27705
    Location:1355 → 1946
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  4. XM_068224641.1 → XP_068080742.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X8

  5. XM_021480147.2 → XP_021335822.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PWG9
    Conserved Domains (5) summary
    cd01780
    Location:2106 → 2205
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1359 → 1810
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    pfam00617
    Location:483 → 668
    RasGEF; RasGEF domain
    cd16203
    Location:1166 → 1346
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cl27705
    Location:1355 → 1960
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  6. XM_021480148.2 → XP_021335823.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q8J1
    Conserved Domains (5) summary
    cd01780
    Location:2105 → 2204
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1359 → 1810
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    pfam00617
    Location:483 → 668
    RasGEF; RasGEF domain
    cd16203
    Location:1166 → 1346
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cl27705
    Location:1355 → 1960
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  7. XM_021480150.2 → XP_021335825.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9QML6
    Conserved Domains (5) summary
    cd01780
    Location:2092 → 2191
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1359 → 1796
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    pfam00617
    Location:483 → 668
    RasGEF; RasGEF domain
    cd16203
    Location:1166 → 1346
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cl27705
    Location:1355 → 1946
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  8. XM_021480149.2 → XP_021335824.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QED9
    Conserved Domains (5) summary
    cd01780
    Location:2097 → 2196
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1350 → 1801
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    pfam00617
    Location:483 → 668
    RasGEF; RasGEF domain
    cd16203
    Location:1157 → 1337
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cl27705
    Location:1346 → 1951
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  9. XM_021480154.2 → XP_021335829.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X10

    UniProtKB/TrEMBL
    A0A8M9QEE4
    Conserved Domains (5) summary
    cd01780
    Location:2082 → 2181
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1350 → 1787
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    pfam00617
    Location:483 → 668
    RasGEF; RasGEF domain
    cd16203
    Location:1157 → 1337
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cl27705
    Location:1346 → 1937
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  10. XM_021480153.2 → XP_021335828.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X9

    UniProtKB/TrEMBL
    A0A8M9Q8J6
    Conserved Domains (5) summary
    cd01780
    Location:1695 → 1794
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:948 → 1399
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    pfam00617
    Location:72 → 257
    RasGEF; RasGEF domain
    cd16203
    Location:755 → 935
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cl27705
    Location:944 → 1549
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
Nucleotide Protein
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