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atp2a2b ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2b [ Danio rerio (zebrafish) ]

Gene ID: 568265, updated on 2-Nov-2024

Summary

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Official Symbol
atp2a2bprovided by ZNC
Official Full Name
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-867
See related
Ensembl:ENSDARG00000005122 AllianceGenome:ZFIN:ZDB-GENE-030131-867
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
SERCA2; fb51e04; fb80c02; zK83D9.6; wu:fb51e04; wu:fb80c02; si:dkey-83d9.6
Summary
Predicted to enable P-type calcium transporter activity. Acts upstream of or within determination of heart left/right asymmetry. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in axis; myotome; pectoral fin; and pectoral fin musculature. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See atp2a2b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (17051047..17108479)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (17014235..17071388)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex, subunit 3 Neighboring gene ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast) Neighboring gene BCR activator of RhoGEF and GTPase Neighboring gene uncharacterized LOC137488793 Neighboring gene uncharacterized LOC137488792 Neighboring gene growth factor independent 1B transcription repressor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Pathway-specific protein domains are predictive for human diseases. Shim JE, et al. PLoS Comput Biol, 2019 May. PMID 31075101, Free PMC Article
  2. Exposure to water-accommodated fractions of two different crude oils alters morphology, cardiac function and swim bladder development in early-life stages of zebrafish. Li X, et al. Chemosphere, 2019 Nov. PMID 31272002
  3. Influences of domoic Acid exposure on cardiac development and the expression of cardiovascular relative genes in zebrafish (Daniorerio) embryos. Hong Z, et al. J Biochem Mol Toxicol, 2015 Jun. PMID 25691335
  4. Transgenerational inheritance of heart disorders caused by paternal bisphenol A exposure. Lombó M, et al. Environ Pollut, 2015 Nov. PMID 26322593
  5. Characterization of the POU5F1 Homologue in Nile Tilapia: From Expression Pattern to Biological Activity. Xiaohuan H, et al. Stem Cells Dev, 2016 Sep 15. PMID 27473876

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of heart left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cardiac muscle contraction by calcium ion signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 2b
Names
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2b
sarcoplasmic/endoplasmic-reticulum Ca(2+) pump gene 2
NP_001025448.1
XP_005161253.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030277.1 → NP_001025448.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2b

    Status: PROVISIONAL

    Source sequence(s)
    AL844518
    UniProtKB/TrEMBL
    A0A8M1N7U6, Q6ZM60
    Related
    ENSDARP00000047200.5, ENSDART00000047201.6
    Conserved Domains (6) summary
    TIGR01116
    Location:47 → 981
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:87 → 334
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:776 → 978
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 66
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:596 → 704
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:413 → 520
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    17051047..17108479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161196.5 → XP_005161253.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2b isoform X1

    UniProtKB/TrEMBL
    A0A0R4IQS8, A0A8M2B848
    Related
    ENSDARP00000136537.1, ENSDART00000161650.3
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 987
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:93 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:782 → 984
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:602 → 710
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 526
    Cation_ATPase; Cation transport ATPase (P-type)
Nucleotide Protein Strain
Heading Accession and Version

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