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grip2a glutamate receptor interacting protein 2a [ Danio rerio (zebrafish) ]

Gene ID: 568084, updated on 2-Nov-2024

Summary

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Official Symbol
grip2aprovided by ZNC
Official Full Name
glutamate receptor interacting protein 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081104-132
See related
Ensembl:ENSDARG00000087187 AllianceGenome:ZFIN:ZDB-GENE-081104-132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
grip2l; fi03h07; wu:fi03h07; si:ch211-150e8.7; si:ch73-250d21.1
Summary
Acts upstream of or within cytoskeleton organization; fin morphogenesis; and germ cell migration. Is expressed in oocyte stage I; oocyte stage II; oocyte stage III; unfertilized egg; and yolk. Orthologous to human GRIP2 (glutamate receptor interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See grip2a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (7205524..7308385, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (7161976..7289659, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and BTB (POZ) domain containing 1 Neighboring gene solute carrier family 6 member 6a Neighboring gene ssu-2 homolog, related sequence 1 Neighboring gene selenoprotein H Neighboring gene histone H3-like centromeric protein A Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor, like Neighboring gene LHFPL tetraspan subfamily member 4b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cortical depth and differential transport of vegetally localized dorsal and germ line determinants in the zebrafish embryo. Welch E, et al. Bioarchitecture, 2014. PMID 26528729, Free PMC Article
  2. The midbody component Prc1-like is required for microtubule reorganization during cytokinesis and dorsal determinant segregation in the early zebrafish embryo. Nair S, et al. Development, 2023 Feb 15. PMID 36789950, Free PMC Article
  3. Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis. Campbell PD, et al. Development, 2015 Sep 1. PMID 26253407, Free PMC Article
  4. Spatio-temporal mRNA tracking in the early zebrafish embryo. Holler K, et al. Nat Commun, 2021 Jun 7. PMID 34099733, Free PMC Article
  5. Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction. Ge X, et al. PLoS Genet, 2014 Jun. PMID 24967891, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fin morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
glutamate receptor-interacting protein 2a
Names
grip2
hec

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123288.1 → NP_001116760.1  glutamate receptor-interacting protein 2a isoform 1

    Status: PROVISIONAL

    Source sequence(s)
    CU302304
    UniProtKB/TrEMBL
    A0A8M1NIJ9, B0V3R3
    Related
    ENSDARP00000086858.5, ENSDART00000092426.7
    Conserved Domains (3) summary
    smart00228
    Location:623 → 708
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:331 → 412
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam11837
    Location:42 → 81
    DUF3357; Domain of unknown function (DUF3357)

  2. NM_001430888.1 → NP_001417817.1  glutamate receptor-interacting protein 2a isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX469901, CABZ01052649, CABZ01052650, CABZ01052651, CABZ01052652, CABZ01052653, CU302304
    UniProtKB/TrEMBL
    A0A8M6Z7M8

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    7205524..7308385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017357357.2 → XP_017212846.1  glutamate receptor-interacting protein 2a isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z0I1

  2. XM_017357358.3 → XP_017212847.1  glutamate receptor-interacting protein 2a isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z252
Nucleotide Protein Strain
Heading Accession and Version

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