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rorb RAR-related orphan receptor B [ Danio rerio (zebrafish) ]

Gene ID: 567943, updated on 2-Nov-2024

Summary

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Official Symbol
rorbprovided by ZNC
Official Full Name
RAR-related orphan receptor Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061204-2
See related
Ensembl:ENSDARG00000033498 AllianceGenome:ZFIN:ZDB-GENE-061204-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rzrb; nr1f2; sb:eu943
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in alar plate midbrain region; immature eye; and nervous system. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 15. Orthologous to human RORB (RAR related orphan receptor B). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See rorb in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (25366677..25377147, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (24766524..24776994, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene wu:fa19b12 Neighboring gene uncharacterized LOC110439811 Neighboring gene transient receptor potential cation channel, subfamily M, member 6 Neighboring gene uncharacterized LOC137495590 Neighboring gene major facilitator superfamily domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mechano-sensory organ regeneration in adults: the zebrafish lateral line as a model. Dufourcq P, et al. Mol Cell Neurosci, 2006 Oct. PMID 16949838
  2. Th17 master transcription factors RORα and RORγ regulate the expression of IL-17C, IL-17D and IL-17F in Cynoglossus semilaevis. Chi H, et al. Dev Comp Immunol, 2016 Feb. PMID 26547017
  3. The zebrafish retinoid-related orphan receptor (ror) gene family. Flores MV, et al. Gene Expr Patterns, 2007 Apr. PMID 17374568
  4. Molecular evidence for the involvement of RORα and RORγ in immune response in teleost. Du L, et al. Fish Shellfish Immunol, 2012 Aug. PMID 22683816
  5. Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erbalpha. Kakizawa T, et al. J Mol Endocrinol, 2007 May. PMID 17496157

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor ROR-beta
Names
retinoid-related orphan receptor b
ror beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082856.1 → NP_001076325.1  nuclear receptor ROR-beta

    See identical proteins and their annotated locations for NP_001076325.1

    Status: PROVISIONAL

    Source sequence(s)
    EF107093
    UniProtKB/TrEMBL
    A3R3J9
    Related
    ENSDARP00000084181.3, ENSDART00000089748.4
    Conserved Domains (2) summary
    cd06939
    Location:217 → 456
    NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
    cd06968
    Location:3 → 97
    NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    25366677..25377147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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