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furinb furin (paired basic amino acid cleaving enzyme) b [ Danio rerio (zebrafish) ]

Gene ID: 566591, updated on 2-Nov-2024

Summary

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Official Symbol
furinbprovided by ZNC
Official Full Name
furin (paired basic amino acid cleaving enzyme) bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040901-2
See related
Ensembl:ENSDARG00000070971 AllianceGenome:ZFIN:ZDB-GENE-040901-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within cartilage development. Predicted to be located in membrane. Predicted to be active in Golgi membrane and trans-Golgi network. Is expressed in several structures, including endoderm; eye; integument; liver; and pleuroperitoneal region. Orthologous to human FURIN (furin, paired basic amino acid cleaving enzyme). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See furinb in Genome Data Viewer
Location:
chromosome: 25
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (8756238..8916915, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (8679170..8839847, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene unc-45 myosin chaperone A Neighboring gene mannosidase, alpha, class 2A, member 2 Neighboring gene uncharacterized LOC137489328 Neighboring gene si:ch211-256a21.4 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration. Khatib AM, et al. PLoS One, 2010 Jul 2. PMID 20625388, Free PMC Article
  2. Loss of unc45a precipitates arteriovenous shunting in the aortic arches. Anderson MJ, et al. Dev Biol, 2008 Jun 15. PMID 18462713, Free PMC Article
  3. Protease-dependent defects in N-cadherin processing drive PMM2-CDG pathogenesis. Klaver EJ, et al. JCI Insight, 2021 Dec 22. PMID 34784297, Free PMC Article
  4. Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor β1a (TGFβ1a). Turpeinen H, et al. J Biol Chem, 2013 Dec 20. PMID 24178295, Free PMC Article
  5. Hepatocyte growth factor signaling in intrapancreatic ductal cells drives pancreatic morphogenesis. Anderson RM, et al. PLoS Genet, 2013. PMID 23935514, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. furin genes may function partially redundantly to activate Endothelin1 signaling in craniofacial patterning
    Title: Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cartilage development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide hormone processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
furin (paired basic amino acid cleaving enzyme) b
NP_001038574.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045109.2 → NP_001038574.2  furin (paired basic amino acid cleaving enzyme) b precursor

    See identical proteins and their annotated locations for NP_001038574.2

    Status: VALIDATED

    Source sequence(s)
    AL935203, CR407564
    UniProtKB/TrEMBL
    A0A8M1NAA5, F1QKU2
    Related
    ENSDARP00000095400.2, ENSDART00000104629.4
    Conserved Domains (6) summary
    cd04059
    Location:114 → 403
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:648 → 683
    FU; Furin-like repeats
    pfam00082
    Location:145 → 428
    Peptidase_S8; Subtilase family
    pfam01483
    Location:485 → 571
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:34 → 108
    S8_pro-domain; Peptidase S8 pro-domain
    cl22855
    Location:606 → 669
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    8756238..8916915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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