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polq polymerase (DNA directed), theta [ Danio rerio (zebrafish) ]

Gene ID: 566079, updated on 18-Sep-2024

Summary

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Official Symbol
polqprovided by ZNC
Official Full Name
polymerase (DNA directed), thetaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040724-232
See related
Ensembl:ENSDARG00000044622 AllianceGenome:ZFIN:ZDB-GENE-040724-232
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
bZ1P14.5; si:rp71-1p14.5
Summary
Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in double-strand break repair via alternative nonhomologous end joining. Predicted to act upstream of or within DNA-dependent DNA replication. Predicted to be located in membrane and nucleus. Predicted to be integral component of membrane. Is expressed in oocyte and testis. Orthologous to human POLQ (DNA polymerase theta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See polq in Genome Data Viewer
Location:
chromosome: 21
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (22851102..22871911, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (22814499..22835272, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene angiopoietin-like 5 Neighboring gene cilia and flagella associated protein 300 Neighboring gene baculoviral IAP repeat containing 2 Neighboring gene DNA damage-induced apoptosis suppressor Neighboring gene PCF11 cleavage and polyadenylation factor subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ν (POLN). Takata K, et al. J Biol Chem, 2015 Oct 2. PMID 26269593, Free PMC Article
  2. Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development. Thyme SB, et al. Cell Rep, 2016 Apr 26. PMID 27149851, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via alternative nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA polymerase theta
XP_009293682.1
XP_021329106.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    22851102..22871911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009295407.4 → XP_009293682.1  DNA polymerase theta

    UniProtKB/TrEMBL
    A0A8M3B4R3, F1Q4P4
    Related
    ENSDARP00000065555.4, ENSDART00000065556.5
    Conserved Domains (6) summary
    cd08638
    Location:2093 → 2571
    DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
    smart00490
    Location:615 → 688
    HELICc; helicase superfamily c-terminal domain
    COG0749
    Location:1905 → 2569
    PolA; DNA polymerase I - 3'-5' exonuclease and polymerase domains [Replication, recombination and repair]
    COG1204
    Location:264 → 1038
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    pfam00270
    Location:303 → 474
    DEAD; DEAD/DEAH box helicase
    cl10012
    Location:1905 → 2081
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

RNA

  1. XR_002456327.2 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395091.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    271863..293096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473431.2 → XP_021329106.1  DNA polymerase theta

    UniProtKB/TrEMBL
    A0A8M9Q371
    Conserved Domains (2) summary
    cd08638
    Location:2096 → 2574
    DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
    cl28231
    Location:264 → 1038
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]

RNA

  1. XR_002457604.2 RNA Sequence

Nucleotide Protein
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