agrn agrin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: agrnprovided by ZNC
Official Full Name: agrinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1033
See related: Ensembl:ENSDARG00000079388 AllianceGenome:ZFIN:ZDB-GENE-030131-1033
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hm:gc12; sb:eu553; wu:fb57e07
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within anterior/posterior pattern specification; nervous system development; and retina layer formation. Predicted to be located in basement membrane and membrane. Predicted to be active in extracellular region. Is expressed in several structures, including immature eye; nervous system; neural tube; notochord; and pronephric duct. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (23485818..23914625)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (23559190..23988136)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle.
Title: Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle.
MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion.
Title: MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion.
These studies provide evidence that a signaling pathway involving agrin, Fgfs and Shh may be a critical target of ethanol exposure during zebrafish embryogenesis.
Title: Forebrain and hindbrain development in zebrafish is sensitive to ethanol exposure involving agrin, Fgf, and sonic hedgehog function.
Agrin expression and function may be a target of ethanol exposure during embryogenesis.
Title: Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish.
Agrin plays an important role in both peripheral and CNS development and also modulates posterior development in zebrafish.
Title: Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish.

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General gene information

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Markers

fd24d12.y1 (e-PCR)
- UniSTS:195334

G47024 (e-PCR)
- UniSTS:107816

z6142 (e-PCR), detects polymorphism
- UniSTS:204858

fb57e07.x1 (e-PCR)
- UniSTS:190780

fb22h01.x1 (e-PCR)
- UniSTS:190315

fd13d01.x1 (e-PCR)
- UniSTS:195182

agrn (e-PCR), detects polymorphism
- UniSTS:205685

G40406 (e-PCR)
- UniSTS:70025

G47655 (e-PCR)
- UniSTS:108429

G39014 (e-PCR)
- UniSTS:14544

G46160 (e-PCR)
- UniSTS:106962

fc39g09.x1 (e-PCR)
- UniSTS:193758

fc96f01.x1 (e-PCR)
- UniSTS:204029

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables laminin binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within receptor clustering	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: agrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177452.1 → NP_001170923.1 agrin precursor

See identical proteins and their annotated locations for NP_001170923.1

Status: PROVISIONAL

Source sequence(s)

EU716327

UniProtKB/TrEMBL

B3GQ72

Related

ENSDARP00000101095.4, ENSDART00000114067.4

Conserved Domains (9) summary

smart00280
Location:487 → 532

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1805 → 1836

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:346 → 386

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1364 → 1514

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1323 → 1351

EGF; EGF-like domain

pfam00053
Location:791 → 833

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1880 → 2011

Laminin_G_1; Laminin G domain

pfam01390
Location:1138 → 1220

SEA; SEA domain

pfam03146
Location:43 → 146

NtA; Agrin NtA domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

23485818..23914625

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021469829.2 → XP_021325504.1 agrin isoform X1

UniProtKB/TrEMBL

A0A8M9PKT2

Conserved Domains (9) summary

smart00280
Location:494 → 539

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1814 → 1845

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:353 → 393

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1369 → 1519

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:798 → 840

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1908 → 2039

Laminin_G_1; Laminin G domain

pfam00008
Location:1328 → 1356

EGF; EGF-like domain

pfam01390
Location:1145 → 1228

SEA; SEA domain

pfam03146
Location:43 → 146

NtA; Agrin NtA domain
XM_009296860.4 → XP_009295135.1 agrin isoform X5

UniProtKB/TrEMBL

A0A8M3B648

Conserved Domains (9) summary

smart00280
Location:494 → 539

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1814 → 1845

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:353 → 393

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1369 → 1519

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1328 → 1356

EGF; EGF-like domain

pfam00053
Location:798 → 840

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1900 → 2031

Laminin_G_1; Laminin G domain

pfam01390
Location:1145 → 1227

SEA; SEA domain

pfam03146
Location:43 → 146

NtA; Agrin NtA domain
XM_009296863.4 → XP_009295138.1 agrin isoform X6

UniProtKB/TrEMBL

A0A8M3ANN0

Conserved Domains (9) summary

smart00280
Location:494 → 539

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1814 → 1845

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:353 → 393

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1369 → 1519

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1328 → 1356

EGF; EGF-like domain

pfam00053
Location:798 → 840

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1889 → 2020

Laminin_G_1; Laminin G domain

pfam01390
Location:1145 → 1227

SEA; SEA domain

pfam03146
Location:43 → 146

NtA; Agrin NtA domain
XM_021469831.2 → XP_021325506.1 agrin isoform X3

UniProtKB/TrEMBL

A0A8M9PT52

Conserved Domains (9) summary

smart00280
Location:494 → 539

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1810 → 1841

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:353 → 393

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1369 → 1519

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:798 → 840

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1904 → 2035

Laminin_G_1; Laminin G domain

pfam00008
Location:1328 → 1356

EGF; EGF-like domain

pfam01390
Location:1145 → 1228

SEA; SEA domain

pfam03146
Location:43 → 146

NtA; Agrin NtA domain
XM_009296864.4 → XP_009295139.1 agrin isoform X7

UniProtKB/TrEMBL

A0A8M3AYE9

Conserved Domains (9) summary

smart00280
Location:494 → 539

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1810 → 1841

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:353 → 393

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1369 → 1519

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1328 → 1356

EGF; EGF-like domain

pfam00053
Location:798 → 840

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1885 → 2016

Laminin_G_1; Laminin G domain

pfam01390
Location:1145 → 1227

SEA; SEA domain

pfam03146
Location:43 → 146

NtA; Agrin NtA domain
XM_021469836.2 → XP_021325511.1 agrin isoform X10

UniProtKB/TrEMBL

A0A8M9PT59

Conserved Domains (9) summary

smart00280
Location:494 → 539

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1705 → 1736

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:353 → 393

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1260 → 1410

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:798 → 840

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1799 → 1930

Laminin_G_1; Laminin G domain

pfam00008
Location:1219 → 1247

EGF; EGF-like domain

pfam01390
Location:1036 → 1119

SEA; SEA domain

pfam03146
Location:43 → 146

NtA; Agrin NtA domain
XM_021469830.2 → XP_021325505.1 agrin isoform X2

UniProtKB/TrEMBL

A0A8M9PWJ8

Conserved Domains (9) summary

smart00280
Location:494 → 539

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1813 → 1844

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:353 → 393

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1368 → 1518

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:797 → 839

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1907 → 2038

Laminin_G_1; Laminin G domain

pfam00008
Location:1327 → 1355

EGF; EGF-like domain

pfam01390
Location:1144 → 1227

SEA; SEA domain

pfam03146
Location:43 → 146

NtA; Agrin NtA domain
XM_068216785.1 → XP_068072886.1 agrin isoform X12
XM_021469832.2 → XP_021325507.1 agrin isoform X4

UniProtKB/TrEMBL

A0A8M9P562

Conserved Domains (9) summary

smart00280
Location:487 → 532

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1807 → 1838

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:346 → 386

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1362 → 1512

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:791 → 833

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1901 → 2032

Laminin_G_1; Laminin G domain

pfam00008
Location:1321 → 1349

EGF; EGF-like domain

pfam01390
Location:1138 → 1221

SEA; SEA domain

pfam03146
Location:43 → 146

NtA; Agrin NtA domain
XM_021469834.2 → XP_021325509.1 agrin isoform X8

UniProtKB/TrEMBL

A0A8M9PKT9

Conserved Domains (8) summary

smart00280
Location:398 → 443

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1718 → 1749

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:257 → 297

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1273 → 1423

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:702 → 744

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1812 → 1943

Laminin_G_1; Laminin G domain

pfam00008
Location:1232 → 1260

EGF; EGF-like domain

pfam01390
Location:1049 → 1132

SEA; SEA domain
XM_021469835.2 → XP_021325510.1 agrin isoform X9

UniProtKB/TrEMBL

A0A8M9PWK3

Conserved Domains (8) summary

smart00280
Location:387 → 432

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1707 → 1738

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:246 → 286

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1262 → 1412

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:691 → 733

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1801 → 1932

Laminin_G_1; Laminin G domain

pfam00008
Location:1221 → 1249

EGF; EGF-like domain

pfam01390
Location:1038 → 1121

SEA; SEA domain
XM_009296867.4 → XP_009295142.1 agrin isoform X11

UniProtKB/TrEMBL

A0A0R4IJ40, A0A8M3AVD3

Related

ENSDARP00000133459.1, ENSDART00000162838.2

Conserved Domains (8) summary

smart00280
Location:387 → 432

KAZAL; Kazal type serine protease inhibitors

cd00054
Location:1703 → 1734

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00104
Location:246 → 286

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

cd00110
Location:1262 → 1412

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:1221 → 1249

EGF; EGF-like domain

pfam00053
Location:691 → 733

Laminin_EGF; Laminin EGF domain

pfam00054
Location:1778 → 1909

Laminin_G_1; Laminin G domain

pfam01390
Location:1038 → 1120

SEA; SEA domain