dgat2 diacylglycerol O-acyltransferase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dgat2provided by ZNC
Official Full Name: diacylglycerol O-acyltransferase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050913-15
See related: Ensembl:ENSDARG00000018846 AllianceGenome:ZFIN:ZDB-GENE-050913-15
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ARAT; zgc:113394
Summary: Predicted to enable diacylglycerol O-acyltransferase activity. Acts upstream of or within lipid homeostasis; regulation of response to endoplasmic reticulum stress; and response to (R)-carnitine. Predicted to be located in lipid droplet and perinuclear endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in male organism. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to several human genes including DGAT2 (diacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (32501970..32524035, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (32558110..32580175, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diacylglycerol O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables retinol O-fatty-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diacylglycerol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glycerol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of response to endoplasmic reticulum stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to (R)-carnitine	IEP Inferred from Expression Pattern more info	PubMed
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: diacylglycerol O-acyltransferase 2

Names: acyl-CoA retinol O-fatty-acyltransferase; diglyceride acyltransferase 2; retinol O-fatty-acyltransferase

NP_001025367.1

EC 2.3.1.20

EC 2.3.1.76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.