hsp90aa1.2 heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsp90aa1.2provided by ZNC
Official Full Name: heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-031001-3
See related: Ensembl:ENSDARG00000024746 AllianceGenome:ZFIN:ZDB-GENE-031001-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb820; hsp90a2; hsp90a.2
Summary: Predicted to enable ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Predicted to be involved in several processes, including cellular response to heat; protein folding; and protein stabilization. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including myelin sheath; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in several structures, including immature eye; mesoderm; musculature system; nervous system; and pericardial region. Orthologous to several human genes including HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (53967596..53981618, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (54178150..54192172, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hsp90aa1.2 activity is required for fast and efficient cell divisions during the guided migration of primordial germ cells towards the gonad region
Title: Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to heat	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to antibiotic	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cold	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to heat	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myelin sheath	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2

Names: heat shock protein 90-alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045073.1 → NP_001038538.1 heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2

See identical proteins and their annotated locations for NP_001038538.1

Status: PROVISIONAL

Source sequence(s)

CR381646

UniProtKB/TrEMBL

B3DIL2, Q5RG12

Related

ENSDARP00000026065.8, ENSDART00000023550.11

Conserved Domains (3) summary

smart00387
Location:38 → 189

HATPase_c; Histidine kinase-like ATPases

PTZ00272
Location:16 → 734

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

pfam00183
Location:194 → 724

HSP90; Hsp90 protein