lifrb LIF receptor subunit alpha b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lifrbprovided by ZNC
Official Full Name: LIF receptor subunit alpha bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080107-2
See related: Ensembl:ENSDARG00000039863 AllianceGenome:ZFIN:ZDB-GENE-080107-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lifr.b; si:dkey-120e24.3
Summary: Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within prolactin signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including immune system; liver; nervous system; notochord; and otic vesicle. Human ortholog(s) of this gene implicated in osteochondrodysplasia and primary localized cutaneous amyloidosis 1. Orthologous to several human genes including LIFR (LIF receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 21

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (21244055..21261453)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (21207418..21224822)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: LIF receptor subunit alpha b

Names: leukemia inhibitory factor receptor alpha b; leukemia inhibitory factor receptor.b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113732.1 → NP_001107204.1 LIF receptor subunit alpha b precursor

See identical proteins and their annotated locations for NP_001107204.1

Status: PROVISIONAL

Source sequence(s)

BN000769

UniProtKB/TrEMBL

A8WH83

Related

ENSDARP00000154113.1, ENSDART00000189665.1

Conserved Domains (2) summary

smart00060
Location:579 → 657

FN3; Fibronectin type 3 domain

cl21522
Location:222 → 256

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

21244055..21261453

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009295324.4 → XP_009293599.1 LIF receptor subunit alpha b isoform X1

See identical proteins and their annotated locations for XP_009293599.1

UniProtKB/TrEMBL

A0A8M3ATV3, F1Q5F5

Related

ENSDARP00000058305.5, ENSDART00000058306.7

Conserved Domains (2) summary

smart00060
Location:588 → 666

FN3; Fibronectin type 3 domain

cl21522
Location:222 → 256

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...