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caskin1 CASK interacting protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 563678, updated on 2-Nov-2024

Summary

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Official Symbol
caskin1provided by ZNC
Official Full Name
CASK interacting protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-071115-3
See related
Ensembl:ENSDARG00000046107 AllianceGenome:ZFIN:ZDB-GENE-071115-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-34b22.2
Summary
Predicted to be located in cytoplasm. Orthologous to human CASKIN1 (CASK interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See caskin1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (35637637..35800810, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (35512530..35671991, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), gamma 13b Neighboring gene TNF receptor-associated factor 7 Neighboring gene cytokine receptor-like factor 3 Neighboring gene SUZ12 polycomb repressive complex 2 subunit a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of Class I cytokine receptors. Liongue C, et al. BMC Evol Biol, 2007 Jul 18. PMID 17640376, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
caskin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    35637637..35800810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068219193.1 → XP_068075294.1  caskin-1 isoform X2

  2. XM_009299611.4 → XP_009297886.1  caskin-1 isoform X12

    UniProtKB/TrEMBL
    A0A8M3AR19
    Related
    ENSDARP00000029294.8, ENSDART00000031390.8
    Conserved Domains (12) summary
    cd09497
    Location:462 → 527
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:528 → 598
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    smart00454
    Location:460 → 523
    SAM; Sterile alpha motif
    cd00204
    Location:43 → 168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:119 → 218
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:7 → 69
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:208 → 261
    Ank_5; Ankyrin repeats (many copies)
    pfam16600
    Location:356 → 403
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1375 → 1434
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:823 → 892
    Caskin-Pro-rich; Proline rich region of Caskin proteins
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    cl17036
    Location:288 → 349
    SH3; Src Homology 3 domain superfamily

  3. XM_009299609.4 → XP_009297884.1  caskin-1 isoform X10

    UniProtKB/TrEMBL
    A0A8M3B8E9
    Related
    ENSDARP00000126312.1, ENSDART00000150911.3
    Conserved Domains (12) summary
    cd09497
    Location:497 → 562
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:563 → 633
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    smart00454
    Location:495 → 558
    SAM; Sterile alpha motif
    cd00204
    Location:43 → 168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:119 → 218
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:7 → 69
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:208 → 261
    Ank_5; Ankyrin repeats (many copies)
    pfam16600
    Location:381 → 438
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1410 → 1469
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:858 → 927
    Caskin-Pro-rich; Proline rich region of Caskin proteins
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    cl17036
    Location:288 → 349
    SH3; Src Homology 3 domain superfamily

  4. XM_009299601.4 → XP_009297876.1  caskin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AY55
    Conserved Domains (12) summary
    cd09497
    Location:583 → 648
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:649 → 719
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    smart00454
    Location:581 → 644
    SAM; Sterile alpha motif
    cd00204
    Location:43 → 168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:119 → 218
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:7 → 69
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:208 → 261
    Ank_5; Ankyrin repeats (many copies)
    pfam16600
    Location:467 → 524
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1496 → 1555
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:944 → 1013
    Caskin-Pro-rich; Proline rich region of Caskin proteins
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    cl17036
    Location:288 → 349
    SH3; Src Homology 3 domain superfamily

  5. XM_021474586.2 → XP_021330261.1  caskin-1 isoform X11

    UniProtKB/TrEMBL
    A0A8M9Q5E2
    Conserved Domains (10) summary
    cd09497
    Location:469 → 534
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:535 → 605
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    cd00204
    Location:43 → 168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:7 → 69
    Ank_4; Ankyrin repeats (many copies)
    pfam16600
    Location:363 → 410
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1382 → 1441
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:830 → 899
    Caskin-Pro-rich; Proline rich region of Caskin proteins
    cl17036
    Location:288 → 349
    SH3; Src Homology 3 domain superfamily
    cl28087
    Location:703 → 829
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  6. XM_009299608.4 → XP_009297883.1  caskin-1 isoform X9

    UniProtKB/TrEMBL
    A0A8M3AQS1
    Conserved Domains (12) summary
    cd09497
    Location:504 → 569
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:570 → 640
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    smart00454
    Location:502 → 565
    SAM; Sterile alpha motif
    cd00204
    Location:43 → 168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:119 → 218
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:7 → 69
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:208 → 261
    Ank_5; Ankyrin repeats (many copies)
    pfam16600
    Location:388 → 445
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1417 → 1476
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:865 → 934
    Caskin-Pro-rich; Proline rich region of Caskin proteins
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    cl17036
    Location:288 → 349
    SH3; Src Homology 3 domain superfamily

  7. XM_068219201.1 → XP_068075302.1  caskin-1 isoform X8

  8. XM_068219194.1 → XP_068075295.1  caskin-1 isoform X4

  9. XM_068219198.1 → XP_068075299.1  caskin-1 isoform X6

  10. XM_068219199.1 → XP_068075300.1  caskin-1 isoform X7

  11. XM_068219197.1 → XP_068075298.1  caskin-1 isoform X5

  12. XM_068219192.1 → XP_068075293.1  caskin-1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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