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METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit [ Homo sapiens (human) ]

Gene ID: 56339, updated on 16-Apr-2024

Summary

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Official Symbol
METTL3provided by HGNC
Official Full Name
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:17563
See related
Ensembl:ENSG00000165819 MIM:612472; AllianceGenome:HGNC:17563
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M6A; IME4; Spo8; MT-A70; hMETTL3
Summary
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 23.5), testis (RPKM 22.1) and 25 other tissues See more
Orthologs
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Genomic context

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See METTL3 in Genome Data Viewer
Location:
14q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (21498138..21511340, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (15695502..15708704, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21966282..21979482, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene RNA, 7SL, cytoplasmic 650, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21905321-21905864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8103 Neighboring gene Sharpr-MPRA regulatory region 12162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21910077-21910995 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21920455-21920954 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21924579-21925130 Neighboring gene uncharacterized LOC124903283 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21925131-21925682 Neighboring gene RAB2B, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8108 Neighboring gene TOX high mobility group box family member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8111 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21987519-21988018 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:21991711-21991897 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21992413-21993240 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21994071-21994898 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:21994899-21995726 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:22002164-22003029 Neighboring gene spalt like transcription factor 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:22010043-22010544 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:22010545-22011044 Neighboring gene MPRA-validated peak2117 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:22025683-22026226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:22026227-22026770 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:22026789-22026975 Neighboring gene RBBP4 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Increased METTL3 expression and m(6)A RNA methylation may contribute to the development of dry eye in primary Sjögren's syndrome. Ma J, et al. BMC Ophthalmol, 2023 Jun 5. PMID 37277716, Free PMC Article
  2. Mettl3 Mediated m6A Methylation Involved in Epithelial-Mesenchymal Transition by Targeting SOCS3/STAT3/SNAI1 in Cigarette Smoking-Induced COPD. Zhang Y, et al. Int J Chron Obstruct Pulmon Dis, 2023. PMID 37275442, Free PMC Article
  3. The Regulatory Network of METTL3 in the Nervous System: Diagnostic Biomarkers and Therapeutic Targets. Su X, et al. Biomolecules, 2023 Apr 11. PMID 37189411, Free PMC Article
  4. Post-transcriptional modification of m(6)A methylase METTL3 regulates ERK-induced androgen-deprived treatment resistance prostate cancer. Li Y, et al. Cell Death Dis, 2023 Apr 24. PMID 37095108, Free PMC Article
  5. METTL3 Mediates Epithelial-Mesenchymal Transition by Modulating FOXO1 mRNA N(6) -Methyladenosine-Dependent YTHDF2 Binding: A Novel Mechanism of Radiation-Induced Lung Injury. Feng Y, et al. Adv Sci (Weinh), 2023 Jun. PMID 37072646, Free PMC Article

See all (313) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m[6]A modification.
    Title: METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m(6)A modification.
  2. Up-regulation of RNA m[6]A methyltransferase like-3 expression contributes to arsenic and benzo[a]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis.
    Title: Up-regulation of RNA m(6)A methyltransferase like-3 expression contributes to arsenic and benzo[a]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis.
  3. METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4.
    Title: METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4.
  4. METTL3-mediated m[6]A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.
    Title: METTL3-mediated m(6)A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.
  5. METTL3 promotes osteogenic differentiation of human umbilical cord mesenchymal stem cells by up-regulating m6A modification of circCTTN.
    Title: METTL3 promotes osteogenic differentiation of human umbilical cord mesenchymal stem cells by up-regulating m6A modification of circCTTN.
  6. METTL3-mediated HSPA9 m6A modification promotes malignant transformation and inhibits cellular senescence by regulating exosomal mortalin protein in cervical cancer.
    Title: METTL3-mediated HSPA9 m6A modification promotes malignant transformation and inhibits cellular senescence by regulating exosomal mortalin protein in cervical cancer.
  7. Redox regulation of m[6]A methyltransferase METTL3 in beta-cells controls the innate immune response in type 1 diabetes.
    Title: Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
  8. METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability.
    Title: METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability.
  9. Transcriptome sequencing analysis reveals miR-30c-5p promotes ferroptosis in cervical cancer and inhibits growth and metastasis of cervical cancer xenografts by targeting the METTL3/KRAS axis.
    Title: Transcriptome sequencing analysis reveals miR-30c-5p promotes ferroptosis in cervical cancer and inhibits growth and metastasis of cervical cancer xenografts by targeting the METTL3/KRAS axis.
  10. METTL3 as a novel diagnosis and treatment biomarker and its association with glycolysis, cuproptosis and ceRNA in oesophageal carcinoma.
    Title: METTL3 as a novel diagnosis and treatment biomarker and its association with glycolysis, cuproptosis and ceRNA in oesophageal carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (330)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC4336

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables S-adenosyl-L-methionine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA m(6)A methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA m(6)A methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA m(6)A methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenosine to inosine editing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dosage compensation by inactivation of X chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endothelial to hematopoietic transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in forebrain radial glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in gliogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA modification NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cap-independent translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in primary miRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of hematopoietic stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
part_of RNA N6-methyladenosine methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA N6-methyladenosine methyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
N6-adenosine-methyltransferase catalytic subunit
Names
N6-adenosine-methyltransferase 70 kDa subunit
adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
mRNA m(6)A methyltransferase
methyltransferase like 3
methyltransferase-like protein 3
NP_062826.2
XP_006720269.1
XP_011535270.1
XP_047287550.1
XP_054232378.1
XP_054232379.1
XP_054232380.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019852.5 → NP_062826.2  N6-adenosine-methyltransferase catalytic subunit

    See identical proteins and their annotated locations for NP_062826.2

    Status: REVIEWED

    Source sequence(s)
    AL161747, BC001650, CA311761, DC295053
    Consensus CDS
    CCDS32044.1
    UniProtKB/Swiss-Prot
    O14736, Q86U44, Q86V05, Q9HB32
    Related
    ENSP00000298717.3, ENST00000298717.9
    Conserved Domains (1) summary
    pfam05063
    Location:389 → 550
    MT-A70

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    21498138..21511340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536968.3 → XP_011535270.1  N6-adenosine-methyltransferase catalytic subunit isoform X1

    Conserved Domains (1) summary
    cl01947
    Location:389 → 528
    MT-A70; MT-A70

  2. XM_006720206.5 → XP_006720269.1  N6-adenosine-methyltransferase catalytic subunit isoform X3

    Conserved Domains (1) summary
    pfam05063
    Location:105 → 266
    MT-A70

  3. XM_047431594.1 → XP_047287550.1  N6-adenosine-methyltransferase catalytic subunit isoform X2

    Related
    ENSP00000445523.1, ENST00000543235.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    15695502..15708704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376403.1 → XP_054232378.1  N6-adenosine-methyltransferase catalytic subunit isoform X1

  2. XM_054376405.1 → XP_054232380.1  N6-adenosine-methyltransferase catalytic subunit isoform X3

  3. XM_054376404.1 → XP_054232379.1  N6-adenosine-methyltransferase catalytic subunit isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86U44.2 GenPept UniProtKB/Swiss-Prot:Q86U44

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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