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klhl38b kelch-like family member 38b [ Danio rerio (zebrafish) ]

Gene ID: 563341, updated on 2-Nov-2024

Summary

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Official Symbol
klhl38bprovided by ZNC
Official Full Name
kelch-like family member 38bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120727-8
See related
Ensembl:ENSDARG00000040278 AllianceGenome:ZFIN:ZDB-GENE-120727-8
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL38 (kelch like family member 38). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See klhl38b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (25245926..25251929)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (25330897..25335646)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene transmembrane immune signaling adaptor TYROBP Neighboring gene LRAT domain containing 2b Neighboring gene F-box protein 32 Neighboring gene PRELI domain containing 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Acute cold stress induces transient MuRF1 upregulation in the skeletal muscle of zebrafish. Tamai S, et al. Biochem Biophys Res Commun, 2022 Jun 11. PMID 35390673
  2. Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids. Chen Q, et al. Chemosphere, 2017 Apr. PMID 28092764
  3. Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity. Gans I, et al. Sci Rep, 2020 Jul 10. PMID 32651405, Free PMC Article
  4. Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos. Willi RA, et al. Sci Total Environ, 2019 Jul 1. PMID 30954817
  5. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 38
Names
kelch-like 38b
unm_hu7869

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    25245926..25251929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_686705.8 → XP_691797.2  kelch-like protein 38

    UniProtKB/TrEMBL
    A0A8N7UVW2, X1WG55
    Related
    ENSDARP00000129210.1, ENSDART00000155220.3
    Conserved Domains (7) summary
    smart00612
    Location:490 → 531
    Kelch; Kelch domain
    smart00875
    Location:145 → 243
    BACK; BTB And C-terminal Kelch
    PHA03098
    Location:34 → 512
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:383 → 427
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:33 → 137
    BTB; BTB/POZ domain
    pfam01344
    Location:523 → 570
    Kelch_1; Kelch motif
    pfam13964
    Location:432 → 469
    Kelch_6; Kelch motif
Nucleotide Protein Strain
Heading Accession and Version

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