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rbpjb recombination signal binding protein for immunoglobulin kappa J region b [ Danio rerio (zebrafish) ]

Gene ID: 563306, updated on 12-Sep-2024

Summary

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Official Symbol
rbpjbprovided by ZNC
Official Full Name
recombination signal binding protein for immunoglobulin kappa J region bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070319-1
See related
Ensembl:ENSDARG00000052091 AllianceGenome:ZFIN:ZDB-GENE-070319-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Su(H)2; su(h)B
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; blood vessel development; and somitogenesis. Predicted to be located in nucleus. Predicted to be part of MAML1-RBP-Jkappa- ICN1 complex. Is expressed in eye and head. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See rbpjb in Genome Data Viewer
Location:
chromosome: 7
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (62080512..62206922)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (61770350..61896760)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496236 Neighboring gene uncharacterized LOC103911431 Neighboring gene uncharacterized LOC137496235 Neighboring gene cholecystokinin A receptor Neighboring gene TBC1 domain family, member 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of the oscillating gene her1 is directly regulated by Hairy/Enhancer of Split, T-box, and Suppressor of Hairless proteins in the zebrafish segmentation clock. Brend T, et al. Dev Dyn, 2009 Nov. PMID 19795510, Free PMC Article
  2. Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Siekmann AF, et al. Nature, 2007 Feb 15. PMID 17259972
  3. her1 and her13.2 are jointly required for somitic border specification along the entire axis of the fish embryo. Sieger D, et al. Dev Biol, 2006 May 1. PMID 16545363
  4. Coordination of symmetric cyclic gene expression during somitogenesis by Suppressor of Hairless involves regulation of retinoic acid catabolism. Echeverri K, et al. Dev Biol, 2007 Jan 15. PMID 17098223
  5. Celf1 regulation of dmrt2a is required for somite symmetry and left-right patterning during zebrafish development. Matsui T, et al. Development, 2012 Oct. PMID 22899848

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adrenal gland development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within artery development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neurogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within podocyte cell fate commitment IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pronephric duct development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pronephric glomerulus development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somitogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of MAML1-RBP-Jkappa- ICN1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
recombination signal binding protein for immunoglobulin kappa J region b
Names
suppressor of hairless 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083551.1 → NP_001077020.1  recombination signal binding protein for immunoglobulin kappa J region b

    See identical proteins and their annotated locations for NP_001077020.1

    Status: PROVISIONAL

    Source sequence(s)
    AY332618
    UniProtKB/TrEMBL
    A0A8M1NCI9, A4FTT4
    Related
    ENSDARP00000087012.5, ENSDART00000092580.7
    Conserved Domains (3) summary
    cd01176
    Location:337 → 433
    IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
    pfam09270
    Location:166 → 315
    BTD; Beta-trefoil DNA-binding domain
    pfam09271
    Location:35 → 164
    LAG1-DNAbind; LAG1, DNA binding

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    62080512..62206922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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