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pi4kb phosphatidylinositol 4-kinase, catalytic, beta [ Danio rerio (zebrafish) ]

Gene ID: 563201, updated on 14-Nov-2024

Summary

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Official Symbol
pi4kbprovided by ZNC
Official Full Name
phosphatidylinositol 4-kinase, catalytic, betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-96
See related
Ensembl:ENSDARG00000040111 AllianceGenome:ZFIN:ZDB-GENE-061013-96
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pik4cb; zgc:152715
Summary
Predicted to enable 1-phosphatidylinositol 4-kinase activity. Acts upstream of or within cilium assembly; inner ear development; and pronephros structural organization. Predicted to be located in mitochondrial outer membrane and rough endoplasmic reticulum membrane. Predicted to be active in cytoplasm and membrane. Is expressed in brain; head; otic vesicle; and sensory system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See pi4kb in Genome Data Viewer
Location:
chromosome: 16
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (38159755..38199760)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (38209688..38249758)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene pogo transposable element derived with ZNF domain b Neighboring gene selenium binding protein 1 Neighboring gene myosin IEb Neighboring gene prune exopolyphosphatase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Establishment of a Ciliogenesis-Associated Signaling Model for Polycystic Kidney Disease. Lu L, et al. Kidney Blood Press Res, 2021. PMID 34469896
  2. Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafish otic vesicle. Feng Y, et al. J Genet Genomics, 2020 Oct 20. PMID 33358778
  3. Phosphatidylinositol 4-kinase β mutations cause nonsyndromic sensorineural deafness and inner ear malformation. Su X, et al. J Genet Genomics, 2020 Oct 20. PMID 33358777
  4. Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1. Feng Y, et al. Gene, 2024 Mar 10. PMID 38135256
  5. Crucial role of phosphatidylinositol 4-kinase IIIalpha in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling. Ma H, et al. J Cell Sci, 2009 Dec 1. PMID 19887586, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1.
    Title: Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1.
  2. Phosphatidylinositol 4-kinase beta is required for the ciliogenesis of zebrafish otic vesicle.
    Title: Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafish otic vesicle.
  3. Phosphatidylinositol 4-kinase beta mutations cause nonsyndromic sensorineural deafness and inner ear malformation.
    Title: Phosphatidylinositol 4-kinase β mutations cause nonsyndromic sensorineural deafness and inner ear malformation.
  4. findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 in mitochondrial function via its association with several mitochondrial proteins.
    Title: Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol 4-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol 4-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inner ear development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner ear development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner ear receptor cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pronephros structural organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within semicircular canal development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within semicircular canal development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-kinase beta
Names
PI4K-beta
PI4KIII-beta
PI4Kbeta
catalytic phosphatidylinositol 4-kinase beta
phosphatidylinositol 4-kinase III beta
phosphatidylinositol 4-kinase, catalytic, beta polypeptide
ptdIns 4-kinase beta
NP_001030149.2
XP_005158276.1
XP_005158277.1
XP_068070083.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034977.2 → NP_001030149.2  phosphatidylinositol 4-kinase beta

    See identical proteins and their annotated locations for NP_001030149.2

    Status: PROVISIONAL

    Source sequence(s)
    BC124584
    UniProtKB/Swiss-Prot
    B5TXD8, Q08BS7, Q49GP3
    Related
    ENSDARP00000058665.4, ENSDART00000058666.6
    Conserved Domains (1) summary
    cd05168
    Location:548 → 835
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    38159755..38199760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158219.5 → XP_005158276.1  phosphatidylinositol 4-kinase beta isoform X1

    UniProtKB/Swiss-Prot
    B5TXD8, Q08BS7, Q49GP3
    UniProtKB/TrEMBL
    A0A8M2B537, F1RBR8
    Related
    ENSDARP00000099330.1, ENSDART00000112165.3
    Conserved Domains (1) summary
    cd05168
    Location:563 → 850
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

  2. XM_005158220.5 → XP_005158277.1  phosphatidylinositol 4-kinase beta isoform X2

    UniProtKB/Swiss-Prot
    B5TXD8, Q08BS7, Q49GP3
    UniProtKB/TrEMBL
    A0A8M2B4L5
    Conserved Domains (1) summary
    cd05168
    Location:561 → 848
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

  3. XM_068213982.1 → XP_068070083.1  phosphatidylinositol 4-kinase beta isoform X3

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394969.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    137588..197630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q49GP3.2 GenPept UniProtKB/Swiss-Prot:Q49GP3

Gene LinkOut

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