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acsf3 acyl-CoA synthetase family member 3 [ Danio rerio (zebrafish) ]

Gene ID: 562292, updated on 2-Nov-2024

Summary

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Official Symbol
acsf3provided by ZNC
Official Full Name
acyl-CoA synthetase family member 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-121026-3
See related
Ensembl:ENSDARG00000059503 AllianceGenome:ZFIN:ZDB-GENE-121026-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to act upstream of or within fatty acid metabolic process. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See acsf3 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (55950294..56037907)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (55648883..55736461)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene CBFA2/RUNX1 partner transcriptional co-repressor 3 Neighboring gene uncharacterized LOC137490678 Neighboring gene cadherin 15, type 1, M-cadherin (myotubule) Neighboring gene SPG7 matrix AAA peptidase subunit, paraplegin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Takashima S, et al. Mol Genet Metab, 2021 Jul. PMID 34016526
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
malonate--CoA ligase ACSF3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    55950294..56037907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477983.2 → XP_021333658.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q2T7, E7F2S8
    Related
    ENSDARP00000077215.5, ENSDART00000082780.7
    Conserved Domains (1) summary
    cd05941
    Location:64 → 566
    MCS; Malonyl-CoA synthetase (MCS)

  2. XM_068222738.1 → XP_068078839.1  malonate--CoA ligase ACSF3, mitochondrial isoform X2

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394712.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    411525..513968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_685690.8 → XP_690782.3  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A2R8QFY7, A0A8N7TB22
    Conserved Domains (1) summary
    cd05941
    Location:64 → 566
    MCS; Malonyl-CoA synthetase (MCS)

  2. XM_068218466.1 → XP_068074567.1  malonate--CoA ligase ACSF3, mitochondrial isoform X3

  3. XM_068218467.1 → XP_068074568.1  malonate--CoA ligase ACSF3, mitochondrial isoform X4

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395269.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    210850..305078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474142.2 → XP_021329817.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A2R8QA86, A0A8M9PF57
    Conserved Domains (1) summary
    cd05941
    Location:64 → 566
    MCS; Malonyl-CoA synthetase (MCS)
Nucleotide Protein Strain
Heading Accession and Version

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