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htr7a 5-hydroxytryptamine (serotonin) receptor 7a [ Danio rerio (zebrafish) ]

Gene ID: 562111, updated on 2-Nov-2024

Summary

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Official Symbol
htr7aprovided by ZNC
Official Full Name
5-hydroxytryptamine (serotonin) receptor 7aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-130530-666
See related
Ensembl:ENSDARG00000056949 AllianceGenome:ZFIN:ZDB-GENE-130530-666
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
htr7; si:dkey-28j9.6
Summary
Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to act upstream of or within several processes, including circadian rhythm; smooth muscle contraction; and vasoconstriction. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See htr7a in Genome Data Viewer
Location:
chromosome: 17
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (23539842..23545722, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (23522101..23525689, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 1a (cardiac muscle) Neighboring gene kinesin family member 20Ba Neighboring gene zgc:65997 Neighboring gene pantothenate kinase 1a Neighboring gene microRNA mir-107b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways. Tang HH, et al. FASEB J, 2023 Apr. PMID 36961387
  2. Temporal and spatial expression of fgfbp genes in zebrafish. Li Y, et al. Gene, 2018 Jun 15. PMID 29551495
  3. Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish. Li Y, et al. iScience, 2023 May 19. PMID 37207274, Free PMC Article
  4. Testicular transcriptome alterations in zebrafish (Danio rerio) exposure to 17β-estradiol. Zheng Y, et al. Chemosphere, 2019 Mar. PMID 30465971
  5. Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model. Sourbron J, et al. ACS Chem Neurosci, 2016 May 18. PMID 26822114

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within circadian rhythm IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vasoconstriction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
5-hydroxytryptamine receptor 7
Names
5-hydroxytryptamine (serotonin) receptor 7
zmp:0000000663

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    23539842..23545722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467406.2 → XP_021323081.1  5-hydroxytryptamine receptor 7

    UniProtKB/TrEMBL
    A0A8M9PVG7, E7FFG8
    Related
    ENSDARP00000073989.4, ENSDART00000079534.6
    Conserved Domains (1) summary
    cd15329
    Location:105 → 443
    7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394988.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    557845..563725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473154.2 → XP_021328829.1  5-hydroxytryptamine receptor 7

    UniProtKB/TrEMBL
    A0A8M9PVG7, E7FFG8
    Conserved Domains (1) summary
    cd15329
    Location:105 → 443
    7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395331.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    123977..127583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_685507.10 → XP_690599.7  5-hydroxytryptamine receptor 7

    UniProtKB/TrEMBL
    A0A8N7T7N6
    Conserved Domains (1) summary
    cd15329
    Location:105 → 443
    7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
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