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tecta tectorin alpha [ Danio rerio (zebrafish) ]

Gene ID: 561355, updated on 2-Nov-2024

Summary

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Official Symbol
tectaprovided by ZNC
Official Full Name
tectorin alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110411-120
See related
Ensembl:ENSDARG00000059558 AllianceGenome:ZFIN:ZDB-GENE-110411-120
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-122g23.2
Summary
Acts upstream of or within otolith tethering. Is expressed in inner ear and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 12; autosomal recessive nonsyndromic deafness 21; and sensorineural hearing loss. Orthologous to human TECTA (tectorin alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See tecta in Genome Data Viewer
Location:
chromosome: 5
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (63176435..63236572, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (62483024..62543251, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene oocyte zinc finger protein XlCOF6-like Neighboring gene ubiquitin specific peptidase 2b Neighboring gene tubulin folding cofactor E-like b Neighboring gene transcription termination factor 1, tandem duplicate 6 Neighboring gene gelsolin b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin. Stooke-Vaughan GA, et al. Development, 2015 Mar 15. PMID 25758224, Free PMC Article
  2. Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear. Jones AA, et al. Front Cell Dev Biol, 2022. PMID 36092694, Free PMC Article
  3. Mutations affecting development of the zebrafish inner ear and lateral line. Whitfield TT, et al. Development, 1996 Dec. PMID 9007244
  4. RA and FGF signalling are required in the zebrafish otic vesicle to pattern and maintain ventral otic identities. Maier EC, et al. PLoS Genet, 2014 Dec. PMID 25473832, Free PMC Article
  5. In vivo and in vitro analysis of starmaker activity in zebrafish otolith biomineralization. Kalka M, et al. FASEB J, 2019 Jun. PMID 30840836

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within otolith development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within otolith tethering IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
alpha-tectorin
Names
rolling stones
rst

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    63176435..63236572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301924.4 → XP_009300199.1  alpha-tectorin isoform X1

    UniProtKB/TrEMBL
    A0A8M3ASW3, F1QK57
    Related
    ENSDARP00000077331.5, ENSDART00000082896.6
    Conserved Domains (11) summary
    smart00216
    Location:717 → 875
    VWD; von Willebrand factor (vWF) type D domain
    smart00241
    Location:1850 → 2102
    ZP; Zona pellucida (ZP) domain
    smart00539
    Location:100 → 256
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00832
    Location:519 → 594
    C8; This domain contains 8 conserved cysteine residues
    pfam00094
    Location:324 → 480
    VWD; von Willebrand factor type D domain
    pfam00100
    Location:1982 → 2102
    Zona_pellucida; Zona pellucida-like domain
    pfam01826
    Location:597 → 650
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1349 → 1420
    C8; C8 domain
    pfam14670
    Location:2132 → 2166
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl02516
    Location:1102 → 1265
    VWD; von Willebrand factor type D domain
    cl17735
    Location:1479 → 1532
    VWC; von Willebrand factor type C domain

  2. XM_017356378.3 → XP_017211867.1  alpha-tectorin isoform X2

    UniProtKB/TrEMBL
    A0A8M6YZF6
    Conserved Domains (8) summary
    smart00216
    Location:717 → 875
    VWD; von Willebrand factor (vWF) type D domain
    smart00539
    Location:100 → 256
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00832
    Location:519 → 594
    C8; This domain contains 8 conserved cysteine residues
    pfam00094
    Location:324 → 480
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:597 → 650
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1349 → 1420
    C8; C8 domain
    cl02516
    Location:1102 → 1265
    VWD; von Willebrand factor type D domain
    cl17735
    Location:1479 → 1532
    VWC; von Willebrand factor type C domain
Nucleotide Protein Strain
Heading Accession and Version

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