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serpinf2a serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a [ Danio rerio (zebrafish) ]

Gene ID: 560308, updated on 12-Sep-2024

Summary

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Official Symbol
serpinf2aprovided by ZNC
Official Full Name
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060822-1
See related
Ensembl:ENSDARG00000076448 AllianceGenome:ZFIN:ZDB-GENE-060822-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
serpinf2; serpinf2l; wu:fd57d08
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in COVID-19 and alpha-2-plasmin inhibitor deficiency. Orthologous to human SERPINF2 (serpin family F member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See serpinf2a in Genome Data Viewer
Location:
chromosome: 21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (40092281..40104916)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (40068744..40081363)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 31 Neighboring gene solute carrier family 13 member 5a Neighboring gene serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 Neighboring gene solute carrier organic anion transporter family, member 2B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae. Wu XM, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31533079
  2. The first characterization of multidrug and toxin extrusion (MATE/SLC47) proteins in zebrafish (Danio rerio). Lončar J, et al. Sci Rep, 2016 Jun 30. PMID 27357367, Free PMC Article
  3. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-2-antiplasmin
Names
serine (or cysteine) peptidase inhibitor, clade F, member 2
serine (or cysteine) peptidase inhibitor, clade F, member 2a
serpin peptidase inhibitor, clade F , member 2, like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    40092281..40104916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_683705.8 → XP_688797.1  alpha-2-antiplasmin

    UniProtKB/TrEMBL
    A0A8N7T5R7, F6NQ58
    Related
    ENSDARP00000123643.1, ENSDART00000145150.3
    Conserved Domains (1) summary
    cl00137
    Location:54 → 388
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein Strain
Heading Accession and Version

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