pcsk5b proprotein convertase subtilisin/kexin type 5b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pcsk5bprovided by ZNC
Official Full Name: proprotein convertase subtilisin/kexin type 5bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070822-7
See related: AllianceGenome:ZFIN:ZDB-GENE-070822-7
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pcsk5; zgc:165659
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in peptide hormone processing. Predicted to act upstream of or within proteolysis. Predicted to be active in Golgi membrane and trans-Golgi network. Is expressed in several structures, including digestive system; fin bud; nervous system; pleuroperitoneal region; and tail bud. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (38649986..38842320, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (38617047..39150140, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PC5.2 transcripts are more ubiquitously expressed within the central nervous system together with specific localization in various organs including liver, intestine, and otic vesicle.
Title: Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development.

Submit: New GeneRIF Correction

General gene information

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Markers

G40224 (e-PCR)
- UniSTS:4900

z45626 (e-PCR), detects polymorphism
- UniSTS:238664

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in peptide hormone processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proprotein convertase subtilisin/kexin type 5b

Names: pc5.2; pcsk5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083829.1 → NP_001077298.1 proprotein convertase subtilisin/kexin type 5b preproprotein

See identical proteins and their annotated locations for NP_001077298.1

Status: VALIDATED

Source sequence(s)

DQ983233

UniProtKB/TrEMBL

Q069L0

Conserved Domains (8) summary

cd04059
Location:131 → 425

Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases

smart00261
Location:783 → 824

FU; Furin-like repeats

cd00064
Location:635 → 686

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00082
Location:167 → 450

Peptidase_S8; Subtilase family

pfam01483
Location:510 → 600

P_proprotein; Proprotein convertase P-domain

pfam08686
Location:877 → 914

PLAC; PLAC (protease and lacunin) domain

pfam14843
Location:634 → 745

GF_recep_IV; Growth factor receptor domain IV

pfam16470
Location:33 → 109

S8_pro-domain; Peptidase S8 pro-domain