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palb2 partner and localizer of BRCA2 [ Danio rerio (zebrafish) ]

Gene ID: 558923, updated on 27-Mar-2024

Summary

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Official Symbol
palb2provided by ZNC
Official Full Name
partner and localizer of BRCA2provided by ZNC
Primary source
ZFIN:ZDB-GENE-090313-43
See related
AllianceGenome:ZFIN:ZDB-GENE-090313-43
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Fancn; si:ch211-14k19.9
Summary
Predicted to enable DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be active in nucleoplasm. Is expressed in brain; eye; immature eye; lens; and pectoral fin fold. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group N; breast cancer; and pancreatic cancer. Orthologous to human PALB2 (partner and localizer of BRCA2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See palb2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (9124996..9134082, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (8440879..8449953, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene si:ch211-14k19.8 Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1a Neighboring gene uncharacterized LOC110439775 Neighboring gene RASD family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The Fanconi anemia/BRCA gene network in zebrafish: embryonic expression and comparative genomics. Titus TA, et al. Mutat Res, 2009 Jul 31. PMID 19101574, Free PMC Article
  2. Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility. Ramanagoudr-Bhojappa R, et al. PLoS Genet, 2018 Dec. PMID 30540754, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
partner and localizer of BRCA2
Names
Fanconi N
Fanconi anemia
complementation group N

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    9124996..9134082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001919731.7 → XP_001919766.3  partner and localizer of BRCA2

    UniProtKB/TrEMBL
    A0A8M1QKC3
    Conserved Domains (2) summary
    pfam12958
    Location:18 → 50
    DUF3847; Protein of unknown function (DUF3847)
    pfam16756
    Location:961 → 1290
    PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394461.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    233271..242152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471112.1 → XP_021326787.1  partner and localizer of BRCA2

    UniProtKB/TrEMBL
    A0A8M9P7S0
    Conserved Domains (2) summary
    pfam12958
    Location:18 → 50
    DUF3847; Protein of unknown function (DUF3847)
    pfam16756
    Location:948 → 1271
    PALB2_WD40; Partner and localizer of BRCA2 WD40 domain
Nucleotide Protein Strain
Heading Accession and Version

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