amotl2a angiomotin like 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: amotl2aprovided by ZNC
Official Full Name: angiomotin like 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9770
See related: Ensembl:ENSDARG00000061923 AllianceGenome:ZFIN:ZDB-GENE-030131-9770
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb308; amotl2; sb:cb308; wu:fc41b07; wu:fc64c06
Summary: Involved in endothelial cell morphogenesis. Acts upstream of or within several processes, including blood vessel morphogenesis; endothelial cell proliferation; and filopodium assembly. Located in cell cortex; cell-cell junction; and polymeric cytoskeletal fiber. Is expressed in several structures, including cardiovascular system; ectoderm; mesoderm; nervous system; and neural plate. Orthologous to human AMOTL2 (angiomotin like 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (27991943..28001090)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (28001456..28008813)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that angiomotin like 2a (AmotL2) and par-3 family cell polarity regulator alpha b (Par3) form a protein complex controlling actin filament induction from adherens junctions.
Title: AmotL2 integrates polarity and junctional cues to modulate cell shape.
Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt/beta-catenin effector Lef1.
Title: Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish.
amotL2 associates to the VE-cadherin adhesion complex where it couples adherens junctions to contractile actin fibres.
Title: AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion.
We demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer beta-catenin2.
Title: The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish.
Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
Title: Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis.
Amotl2 interacts preferentially with and facilitates translocation of the phosphorylated c-Src, which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.
Title: Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation.

Submit: New GeneRIF Correction

General gene information

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Markers

fa01a09.s1 (e-PCR)
- UniSTS:202110

fc64c06.y1 (e-PCR)
- UniSTS:194186

fc41b02.x1 (e-PCR)
- UniSTS:188132

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal aorta development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal aorta morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal aorta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity involved in ameboidal cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell shape	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in podosome	ISS Inferred from Sequence or Structural Similarity more info
located_in polymeric cytoskeletal fiber	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: angiomotin-like 2a

Names: angiomotin like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.