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lgr4 leucine-rich repeat containing G protein-coupled receptor 4 [ Danio rerio (zebrafish) ]

Gene ID: 558825, updated on 27-Mar-2024

Summary

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Official Symbol
lgr4provided by ZNC
Official Full Name
leucine-rich repeat containing G protein-coupled receptor 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-111013-1
See related
Ensembl:ENSDARG00000060542 AllianceGenome:ZFIN:ZDB-GENE-111013-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable transmembrane signaling receptor activity. Involved in hypothalamus gonadotrophin-releasing hormone neuron development. Predicted to be integral component of plasma membrane. Is expressed in several structures, including Kupffer's vesicle; central nervous system; digestive system; head; and pectoral fin bud. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See lgr4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (32367250..32460223)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (32097806..32189073)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene methyltransferase 15, mitochondrial 12S rRNA N4-cytidine Neighboring gene uncharacterized LOC103911388 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 4 Neighboring gene follicle stimulating hormone subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression patterns of lgr4 and lgr6 during zebrafish development. Hirose K, et al. Gene Expr Patterns, 2011 Oct. PMID 21570488
  2. LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling. Mancini A, et al. JCI Insight, 2020 Jun 4. PMID 32493844, Free PMC Article
  3. Distinct tooth regeneration systems deploy a conserved battery of genes. Square TA, et al. Evodevo, 2021 Mar 25. PMID 33766133, Free PMC Article
  4. An in vivo requirement for the mediator subunit med14 in the maintenance of stem cell populations. Burrows JT, et al. Stem Cell Reports, 2015 Apr 14. PMID 25772472, Free PMC Article
  5. Specific miRNA-G Protein-Coupled Receptor Networks Regulate Sox9a/Sox9b Activities to Promote Gonadal Rejuvenation in Zebrafish. Guo H, et al. Stem Cells, 2019 Sep. PMID 31116894

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in hypothalamus gonadotrophin-releasing hormone neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353862.1 → NP_001340791.1  leucine-rich repeat-containing G-protein coupled receptor 4 precursor

    Status: VALIDATED

    Source sequence(s)
    BX511109
    UniProtKB/Swiss-Prot
    E7FE13
    UniProtKB/TrEMBL
    A0A8M9QHT5
    Conserved Domains (4) summary
    COG4886
    Location:137 → 452
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:84 → 144
    LRR_8; Leucine rich repeat
    cd15361
    Location:527 → 811
    7tmA_LGR4; leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    32367250..32460223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_682092.9 → XP_687184.4  leucine-rich repeat-containing G-protein coupled receptor 4

    UniProtKB/Swiss-Prot
    E7FE13
    Related
    ENSDARP00000137036.1, ENSDART00000169588.3
    Conserved Domains (4) summary
    COG4886
    Location:137 → 452
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:84 → 144
    LRR_8; Leucine rich repeat
    cd15361
    Location:527 → 811
    7tmA_LGR4; leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_021477865.1 → XP_021333540.1  leucine-rich repeat-containing G-protein coupled receptor 4

    UniProtKB/Swiss-Prot
    E7FE13
    UniProtKB/TrEMBL
    A0A8M9QHT5
    Related
    ENSDARP00000149657.1, ENSDART00000180544.1
    Conserved Domains (4) summary
    COG4886
    Location:137 → 452
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:64 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:84 → 144
    LRR_8; Leucine rich repeat
    cd15361
    Location:527 → 811
    7tmA_LGR4; leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E7FE13.1 GenPept UniProtKB/Swiss-Prot:E7FE13

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