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cacnb2b calcium channel, voltage-dependent, beta 2b [ Danio rerio (zebrafish) ]

Gene ID: 558806, updated on 6-Jun-2024

Summary

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Official Symbol
cacnb2bprovided by ZNC
Official Full Name
calcium channel, voltage-dependent, beta 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-129
See related
Ensembl:ENSDARG00000055565 AllianceGenome:ZFIN:ZDB-GENE-050208-129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cacnb2a; CACNB2.2; im:7141271; si:dkey-32m20.2
Summary
Predicted to enable high voltage-gated calcium channel activity. Predicted to be involved in chemical synaptic transmission; neuromuscular junction development; and regulation of voltage-gated calcium channel activity. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See cacnb2b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31462762..31539459)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31479544..31556241)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 Neighboring gene transmembrane protein 236 Neighboring gene mannose receptor, C type 1b Neighboring gene si:ch211-106h4.4 Neighboring gene uncharacterized LOC110438058 Neighboring gene si:ch211-106h4.5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The calcium channel beta2 (CACNB2) subunit repertoire in teleosts. Ebert AM, et al. BMC Mol Biol, 2008 Apr 17. PMID 18419826, Free PMC Article
  2. Comparative genomic analysis of slc39a12/ZIP12: insight into a zinc transporter required for vertebrate nervous system development. Chowanadisai W. PLoS One, 2014. PMID 25375179, Free PMC Article
  3. Voltage-gated calcium channel CACNB2 (β2.1) protein is required in the heart for control of cell proliferation and heart tube integrity. Chernyavskaya Y, et al. Dev Dyn, 2012 Apr. PMID 22274990
  4. Identification and expression of voltage-gated calcium channel beta subunits in Zebrafish. Zhou W, et al. Dev Dyn, 2008 Dec. PMID 19035348
  5. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
voltage-dependent L-type calcium channel subunit beta-2b
Names
CAB2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423728.1 → NP_001410657.1  voltage-dependent L-type calcium channel subunit beta-2b isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR293515, CT027716

  2. NM_001423729.1 → NP_001410658.1  voltage-dependent L-type calcium channel subunit beta-2b isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR293515, CT027716
    UniProtKB/TrEMBL
    C9VXY1

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    31462762..31539459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081748.2: Suppressed sequence

    Description
    NM_001081748.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

  2. NM_001166324.1: Suppressed sequence

    Description
    NM_001166324.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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