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ADAP2 ArfGAP with dual PH domains 2 [ Homo sapiens (human) ]

Gene ID: 55803, updated on 14-Nov-2024

Summary

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Official Symbol
ADAP2provided by HGNC
Official Full Name
ArfGAP with dual PH domains 2provided by HGNC
Primary source
HGNC:HGNC:16487
See related
Ensembl:ENSG00000184060 MIM:608635; AllianceGenome:HGNC:16487
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENTA2; cent-b; HSA272195
Summary
The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016]
Expression
Broad expression in spleen (RPKM 10.3), placenta (RPKM 9.9) and 23 other tissues See more
Orthologs
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Genomic context

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See ADAP2 in Genome Data Viewer
Location:
17q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (30921945..30959322)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (31867653..31905026)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29248963..29286340)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATPase family AAA domain containing 5 Neighboring gene RNA, U6 small nuclear 298, pseudogene Neighboring gene MPRA-validated peak2795 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29233994-29234794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29239185-29239684 Neighboring gene transcription elongation factor, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8404 Neighboring gene MPRA-validated peak2796 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29284865-29285364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8405 Neighboring gene RNA, 7SL, cytoplasmic 138, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12005 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:29297471-29298032 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:29298033-29298594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12007 Neighboring gene ring finger protein 135 Neighboring gene divergent-paired related homeobox pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Elevated Expression of ADAP2 is Associated With Aggressive Behavior of Human Clear-Cell Renal Cell Carcinoma and Poor Patient Survival. Qiang Y, et al. Clin Genitourin Cancer, 2023 Apr. PMID 36127253
  2. Centaurin-α₂ interacts with β-tubulin and stabilizes microtubules. Zuccotti P, et al. PLoS One, 2012. PMID 23285209, Free PMC Article
  3. Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle. Whitley P, et al. Eur J Cell Biol, 2002 Apr. PMID 12018390
  4. Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins. Hanck T, et al. J Neurochem, 2004 Jan. PMID 14690521
  5. ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry. Shu Q, et al. PLoS Pathog, 2015 Sep. PMID 26372645, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated Expression of ADAP2 is Associated With Aggressive Behavior of Human Clear-Cell Renal Cell Carcinoma and Poor Patient Survival.
    Title: Elevated Expression of ADAP2 is Associated With Aggressive Behavior of Human Clear-Cell Renal Cell Carcinoma and Poor Patient Survival.
  2. ArfGAP domain-containing protein 2 (ADAP2) is identified as a key novel scaffolding protein that integrates different modules of the RIG-I pathway, located at distinct subcellular locations, and mediates cellular antiviral type I interferon production.
    Title: ArfGAP Domain-Containing Protein 2 (ADAP2) Integrates Upstream and Downstream Modules of RIG-I Signaling and Facilitates Type I Interferon Production.
  3. Data suggest ADAP2 (an interferon-beta stimulated gene) disrupts pathogenic internalization of some RNA viruses/virions (dengue, vesicular stomatitis) by altering ADP ribosylation factor 6-mediated processes including up-regulation of pinocytosis.
    Title: ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.
  4. Centaurin-alpha interacts with beta-tubulin and stabilizes microtubules.
    Title: Centaurin-α₂ interacts with β-tubulin and stabilizes microtubules.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
  7. The human gene for centaurin alpha 2 is located on chromosome 17, position 17q11.2, near the neurofibromatosis 1 (NF1) locus and concentrated at the plasma membrane.
    Title: Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol 1,3,4,5 tetrakisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial envelope ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
arf-GAP with dual PH domain-containing protein 2
Names
centaurin beta
centaurin-alpha 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051975.1 RefSeqGene

    Range
    5210..42587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346712.2 → NP_001333641.1  arf-GAP with dual PH domain-containing protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC138207
    Consensus CDS
    CCDS86588.1
    UniProtKB/TrEMBL
    Q2V6Q1, Q53HQ4
    Related
    ENSP00000464121.1, ENST00000580525.6

  2. NM_001346714.2 → NP_001333643.1  arf-GAP with dual PH domain-containing protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC138207, BC033758
    UniProtKB/TrEMBL
    Q53HQ4
    Conserved Domains (3) summary
    cd01251
    Location:255 → 361
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:133 → 241
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8 → 126
    ArfGap; Putative GTPase activating protein for Arf

  3. NM_001346716.2 → NP_001333645.1  arf-GAP with dual PH domain-containing protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC138207
    UniProtKB/TrEMBL
    Q53HQ4

  4. NM_018404.3 → NP_060874.1  arf-GAP with dual PH domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_060874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC138207, AJ272195, BC033758
    Consensus CDS
    CCDS11261.1
    UniProtKB/Swiss-Prot
    Q8N4Q6, Q96SD5, Q9NPF8
    UniProtKB/TrEMBL
    Q53HQ4
    Related
    ENSP00000329468.3, ENST00000330889.8
    Conserved Domains (4) summary
    cd01251
    Location:255 → 362
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:133 → 241
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:258 → 361
    PH; PH domain
    pfam01412
    Location:8 → 126
    ArfGap; Putative GTPase activating protein for Arf

RNA

  1. NR_144488.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC138207

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    30921945..30959322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450834.2 → XP_024306602.1  arf-GAP with dual PH domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    Q53HQ4
    Conserved Domains (3) summary
    cd13252
    Location:139 → 247
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8 → 132
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:261 → 353
    PH-like; Pleckstrin homology-like domain

  2. XM_024450832.2 → XP_024306600.1  arf-GAP with dual PH domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    Q53HQ4
    Conserved Domains (3) summary
    cd01251
    Location:261 → 367
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:139 → 247
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8 → 132
    ArfGap; Putative GTPase activating protein for Arf

  3. XM_024450833.2 → XP_024306601.1  arf-GAP with dual PH domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q53HQ4
    Conserved Domains (3) summary
    cd13252
    Location:139 → 247
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8 → 132
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:254 → 347
    PH-like; Pleckstrin homology-like domain

  4. XM_024450835.2 → XP_024306603.1  arf-GAP with dual PH domain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    cd01251
    Location:133 → 240
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:11 → 119
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791803.1 Reference GRCh38.p14 PATCHES

    Range
    1119..38496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333216.1 → XP_054189191.1  arf-GAP with dual PH domain-containing protein 2 isoform X3

  2. XM_054333214.1 → XP_054189189.1  arf-GAP with dual PH domain-containing protein 2 isoform X1

  3. XM_054333215.1 → XP_054189190.1  arf-GAP with dual PH domain-containing protein 2 isoform X2

  4. XM_054333217.1 → XP_054189192.1  arf-GAP with dual PH domain-containing protein 2 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    31867653..31905026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316649.1 → XP_054172624.1  arf-GAP with dual PH domain-containing protein 2 isoform X3

  2. XM_054316647.1 → XP_054172622.1  arf-GAP with dual PH domain-containing protein 2 isoform X1

  3. XM_054316648.1 → XP_054172623.1  arf-GAP with dual PH domain-containing protein 2 isoform X2

  4. XM_054316650.1 → XP_054172625.1  arf-GAP with dual PH domain-containing protein 2 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPF8.1 GenPept UniProtKB/Swiss-Prot:Q9NPF8

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