U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MCTP2 multiple C2 and transmembrane domain containing 2 [ Homo sapiens (human) ]

Gene ID: 55784, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
MCTP2provided by HGNC
Official Full Name
multiple C2 and transmembrane domain containing 2provided by HGNC
Primary source
HGNC:HGNC:25636
See related
Ensembl:ENSG00000140563 MIM:616297; AllianceGenome:HGNC:25636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Located in cytosol; membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen (RPKM 5.6), placenta (RPKM 4.8) and 21 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MCTP2 in Genome Data Viewer
Location:
15q26.2
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (94231366..94483952)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (91994258..92247994)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (94774790..95027181)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370984 Neighboring gene H3 histone pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6851 Neighboring gene ribosomal protein L26 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10135 Neighboring gene long intergenic non-protein coding RNA 2852 Neighboring gene uncharacterized LOC105370986

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE). Djurovic S, et al. Psychiatry Res, 2009 Aug 15. PMID 19223264
  2. MCTP2 is a dosage-sensitive gene required for cardiac outflow tract development. Lalani SR, et al. Hum Mol Genet, 2013 Nov 1. PMID 23773997, Free PMC Article
  3. Human genetics of face recognition: discovery of MCTP2 mutations in humans with face blindness (congenital prosopagnosia). Sun Y, et al. Genetics, 2024 Jun 5. PMID 38547502
  4. Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains. Joshi AS, et al. Mol Biol Cell, 2021 Jun 1. PMID 33826368, Free PMC Article
  5. CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis. Liu Y, et al. J Egypt Natl Canc Inst, 2024 Mar 18. PMID 38494582

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human genetics of face recognition: discovery of MCTP2 mutations in humans with face blindness (congenital prosopagnosia).
    Title: Human genetics of face recognition: discovery of MCTP2 mutations in humans with face blindness (congenital prosopagnosia).
  2. CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.
    Title: CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.
  3. Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains.
    Title: Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains.
  4. Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression.
    Title: Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression.
  5. Results identify MCTP2 as a novel genetic cause of coarctation of the aorta and related cardiac malformations.
    Title: MCTP2 is a dosage-sensitive gene required for cardiac outflow tract development.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. The present study suggested that MCPT2 gene as aputative susceptibility gene for schizophrenia of Scandinavian origin.
    Title: Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE).
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE).
  9. MCTPs are evolutionarily conserved C2 domain proteins that are unusual in that the C2 domains are anchored in the membrane by two closely spaced transmembrane regions and represent Ca(2+)-binding but not phospholipid-binding modules
    Title: Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and performance on standardized cognitive tests.
EBI GWAS Catalog
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.
EBI GWAS Catalog
Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
EBI GWAS Catalog
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog
Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
EBI GWAS Catalog
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
EBI GWAS Catalog
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.
EBI GWAS Catalog
New susceptibility loci associated with kidney disease in type 1 diabetes.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ11175, FLJ33303, MGC111402

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-mediated signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
multiple C2 and transmembrane domain-containing protein 2
Names
multiple C2 domains, transmembrane 2
multiple C2-domains with two transmembrane regions 2 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159643.2 → NP_001153115.1  multiple C2 and transmembrane domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001153115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is lacking two consecutive in-frame coding exons compared to variant 1, resulting in a shorter isoform (2) missing an internal protein segment compared to isoform 1. Variants 2 and 7 both encode the same isoform (2).
    Source sequence(s)
    AC103749, AC110027, AC135626
    Consensus CDS
    CCDS53975.1
    UniProtKB/Swiss-Prot
    Q6DN12
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:716 → 769
    PRT_C; Plant phosphoribosyltransferase C-terminal

  2. NM_001159644.2 → NP_001153116.1  multiple C2 and transmembrane domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001153116.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate segment at the 5' end, and an alternate exon at the 3' end (causing a frame-shift) compared to variant 1. This results in translation initiation from a downstream start codon and a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC103749, BC025708, DA862691
    Consensus CDS
    CCDS53976.1
    UniProtKB/Swiss-Prot
    Q6DN12
    Related
    ENSP00000454847.1, ENST00000557742.1
    Conserved Domains (2) summary
    cd08377
    Location:97 → 215
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cl14603
    Location:1 → 57
    C2; C2 domain

  3. NM_001385001.1 → NP_001371930.1  multiple C2 and transmembrane domain-containing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 5, and 6, encodes isoform 1.
    Source sequence(s)
    AC103749, AC110027, AC135626
    Consensus CDS
    CCDS32338.1
    UniProtKB/Swiss-Prot
    A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
    Related
    ENSP00000350377.4, ENST00000357742.10
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:771 → 824
    PRT_C; Plant phosphoribosyltransferase C-terminal

  4. NM_001385002.1 → NP_001371931.1  multiple C2 and transmembrane domain-containing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 4, and 6, encodes isoform 1.
    Source sequence(s)
    AC103749, AC110027, AC135626
    Consensus CDS
    CCDS32338.1
    UniProtKB/Swiss-Prot
    A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:771 → 824
    PRT_C; Plant phosphoribosyltransferase C-terminal

  5. NM_001385003.1 → NP_001371932.1  multiple C2 and transmembrane domain-containing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 4, and 5, encodes isoform 1.
    Source sequence(s)
    AC103749, AC110027, AC135626
    Consensus CDS
    CCDS32338.1
    UniProtKB/Swiss-Prot
    A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:771 → 824
    PRT_C; Plant phosphoribosyltransferase C-terminal

  6. NM_001385004.1 → NP_001371933.1  multiple C2 and transmembrane domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC103749, AC110027, AC135626
    Consensus CDS
    CCDS53975.1
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:716 → 769
    PRT_C; Plant phosphoribosyltransferase C-terminal

  7. NM_001385005.1 → NP_001371934.1  multiple C2 and transmembrane domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:757 → 810
    PRT_C; Plant phosphoribosyltransferase C-terminal

  8. NM_001385006.1 → NP_001371935.1  multiple C2 and transmembrane domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:730 → 783
    PRT_C; Plant phosphoribosyltransferase C-terminal

  9. NM_001385007.1 → NP_001371936.1  multiple C2 and transmembrane domain-containing protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626
    Conserved Domains (4) summary
    cd04042
    Location:101 → 220
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:263 → 375
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:415 → 533
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:677 → 730
    PRT_C; Plant phosphoribosyltransferase C-terminal

  10. NM_001385008.1 → NP_001371937.1  multiple C2 and transmembrane domain-containing protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626
    Conserved Domains (3) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

  11. NM_001385009.1 → NP_001371938.1  multiple C2 and transmembrane domain-containing protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626
    Conserved Domains (4) summary
    cd04042
    Location:29 → 148
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:191 → 303
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:343 → 461
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:605 → 658
    PRT_C; Plant phosphoribosyltransferase C-terminal

  12. NM_001385010.1 → NP_001371939.1  multiple C2 and transmembrane domain-containing protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626
    Conserved Domains (4) summary
    cd04042
    Location:29 → 148
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:191 → 303
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:343 → 461
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:550 → 603
    PRT_C; Plant phosphoribosyltransferase C-terminal

  13. NM_001385011.1 → NP_001371940.1  multiple C2 and transmembrane domain-containing protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626
    Conserved Domains (3) summary
    cd04042
    Location:101 → 220
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:251 → 363
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:403 → 521
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

  14. NM_018349.4 → NP_060819.3  multiple C2 and transmembrane domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_060819.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 4-6 all encode the same isoform (1).
    Source sequence(s)
    AC103749, AC110027, AC135626
    Consensus CDS
    CCDS32338.1
    UniProtKB/Swiss-Prot
    A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:771 → 824
    PRT_C; Plant phosphoribosyltransferase C-terminal

RNA

  1. NR_169526.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626

  2. NR_169527.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626

  3. NR_169528.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626

  4. NR_169529.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626

  5. NR_169530.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626

  6. NR_169531.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626

  7. NR_169532.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC103749, AC110027, AC135626

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    94231366..94483952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432839.1 → XP_047288795.1  multiple C2 and transmembrane domain-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:771 → 824
    PRT_C; Plant phosphoribosyltransferase C-terminal

  2. XM_047432840.1 → XP_047288796.1  multiple C2 and transmembrane domain-containing protein 2 isoform X1

    Related
    ENSP00000395109.3, ENST00000451018.7

  3. XM_011521774.3 → XP_011520076.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

    Conserved Domains (3) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

  4. XM_047432842.1 → XP_047288798.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

  5. XM_047432843.1 → XP_047288799.1  multiple C2 and transmembrane domain-containing protein 2 isoform X3

  6. XM_047432841.1 → XP_047288797.1  multiple C2 and transmembrane domain-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    A2RRC2, C6G483, C6G484, Q49AB0, Q6DN12, Q8TAX2, Q9NUS2, Q9NUW7
    Conserved Domains (4) summary
    cd04042
    Location:195 → 314
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:357 → 469
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:509 → 627
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:771 → 824
    PRT_C; Plant phosphoribosyltransferase C-terminal

  7. XM_005254960.2 → XP_005255017.1  multiple C2 and transmembrane domain-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_005255017.1

    UniProtKB/Swiss-Prot
    Q6DN12
    Conserved Domains (3) summary
    cd08377
    Location:97 → 215
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:359 → 412
    PRT_C; Plant phosphoribosyltransferase C-terminal
    cl14603
    Location:1 → 57
    C2; C2 domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    91994258..92247994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378418.1 → XP_054234393.1  multiple C2 and transmembrane domain-containing protein 2 isoform X6

  2. XM_054378423.1 → XP_054234398.1  multiple C2 and transmembrane domain-containing protein 2 isoform X7

  3. XM_054378420.1 → XP_054234395.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

  4. XM_054378419.1 → XP_054234394.1  multiple C2 and transmembrane domain-containing protein 2 isoform X1

  5. XM_054378421.1 → XP_054234396.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

  6. XM_054378422.1 → XP_054234397.1  multiple C2 and transmembrane domain-containing protein 2 isoform X3

  7. XM_054378424.1 → XP_054234399.1  multiple C2 and transmembrane domain-containing protein 2 isoform X8

  8. XM_054378425.1 → XP_054234400.1  multiple C2 and transmembrane domain-containing protein 2 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DN12.3 GenPept UniProtKB/Swiss-Prot:Q6DN12

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools