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adamtsl7 ADAMTS-like 7 [ Danio rerio (zebrafish) ]

Gene ID: 556634, updated on 2-Nov-2024

Summary

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Official Symbol
adamtsl7provided by ZNC
Official Full Name
ADAMTS-like 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-070816-2
See related
Ensembl:ENSDARG00000055439 AllianceGenome:ZFIN:ZDB-GENE-070816-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human THSD4 (thrombospondin type 1 domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See adamtsl7 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (21576152..21599550, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (20883735..20906347, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene non-SMC condensin II complex, subunit D3 Neighboring gene primase and polymerase (DNA-directed) Neighboring gene zinc finger, CCHC domain containing 7 Neighboring gene si:ch211-134c9.2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver. Xu H, et al. PLoS One, 2013. PMID 23922661, Free PMC Article
  2. A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium. Lu F, et al. Sci Rep, 2023 Feb 23. PMID 36823429, Free PMC Article
  3. The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. Huxley-Jones J, et al. BMC Evol Biol, 2007 Apr 17. PMID 17439641, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thrombospondin type-1 domain-containing protein 4
Names
ADAMTSLb

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    21576152..21599550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476316.2 → XP_021331991.1  thrombospondin type-1 domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q909
    Conserved Domains (3) summary
    smart00209
    Location:361 → 418
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:82 → 183
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:601 → 631
    PLAC; PLAC (protease and lacunin) domain

  2. XM_068221181.1 → XP_068077282.1  thrombospondin type-1 domain-containing protein 4 isoform X2

    Related
    ENSDARP00000114703.1, ENSDART00000148327.2

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394478.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    169216..192668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356043.3 → XP_017211532.2  thrombospondin type-1 domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YZ16
    Conserved Domains (3) summary
    smart00209
    Location:361 → 418
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:82 → 183
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:601 → 631
    PLAC; PLAC (protease and lacunin) domain

  2. XM_068218000.1 → XP_068074101.1  thrombospondin type-1 domain-containing protein 4 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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