nsd1a nuclear receptor binding SET domain protein 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nsd1aprovided by ZNC
Official Full Name: nuclear receptor binding SET domain protein 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080519-3
See related: Ensembl:ENSDARG00000060016 AllianceGenome:ZFIN:ZDB-GENE-080519-3
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable histone H3K36 methyltransferase activity. Acts upstream of or within heterochromatin formation. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Sotos syndrome; Sotos syndrome 1; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (49152342..49211341)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (50164365..50223481)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G47740 (e-PCR)
- UniSTS:108511

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables histone H3K36 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein-containing complex organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase, H3 lysine-36 specific

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

49152342..49211341

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_678798.9 → XP_683890.4 histone-lysine N-methyltransferase, H3 lysine-36 specific

UniProtKB/TrEMBL

A0A8N7UUM6, F1QA79

Related

ENSDARP00000078549.4, ENSDART00000084114.6

Conserved Domains (10) summary

cd05838
Location:1437 → 1531

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1574 → 1624

AWS; associated with SET domains

smart00317
Location:1626 → 1748

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG5034
Location:1108 → 1270

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1228 → 1270

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15653
Location:1322 → 1375

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1392 → 1431

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:1802 → 1844

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cl02554
Location:285 → 382

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

cl22851
Location:1275 → 1321

PHD_SF; PHD finger superfamily