slc2a1a solute carrier family 2 member 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc2a1aprovided by ZNC
Official Full Name: solute carrier family 2 member 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3158
See related: Ensembl:ENSDARG00000001437 AllianceGenome:ZFIN:ZDB-GENE-030131-3158
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: glut1; glut1a; glut1b; slc2a1; fc29a02; wu:fc29a02
Summary: Enables D-glucose transmembrane transporter activity. Acts upstream of or within several processes, including D-glucose import; endothelial cell development; and vasculature development. Predicted to be located in membrane. Predicted to be active in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including cardiovascular system; intermediate mesoderm; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (22200467..22212586)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (22273916..22285975)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

akt2 has a role in an integrative pathway directly linking glucose, Glut1 expression, and activation of apoptosis
Title: Akt2 modulates glucose availability and downstream apoptotic pathways during development.
A tractable system for elucidating the cellular and molecular mechanisms of Glut1 deficiency and in vivo genetic evidence directly linking nutrient availability and activation of apoptosis during embryonic brain development are presented.
Title: GLUT1 deficiency links nutrient availability and apoptosis during embryonic development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-glucose import	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within D-glucose import	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellum vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endothelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insulin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 1a

Names: facilitated glucose transporter 1; solute carrier family 2 (facilitated glucose transporter), member 1a; solute carrier family 2, member 1; zglut1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039808.2 → NP_001034897.1 solute carrier family 2, facilitated glucose transporter member 1a

See identical proteins and their annotated locations for NP_001034897.1

Status: VALIDATED

Source sequence(s)

AL772391

UniProtKB/TrEMBL

A0A8M1N8E0, Q285P3

Related

ENSDARP00000022579.6, ENSDART00000025414.7

Conserved Domains (2) summary

cd06174
Location:62 → 450

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 467

Sugar_tr; Sugar (and other) transporter