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orc1 origin recognition complex, subunit 1 [ Danio rerio (zebrafish) ]

Gene ID: 554509, updated on 2-Nov-2024

Summary

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Official Symbol
orc1provided by ZNC
Official Full Name
origin recognition complex, subunit 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6960
See related
Ensembl:ENSDARG00000039217 AllianceGenome:ZFIN:ZDB-GENE-030131-6960
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
orc1l; zgc:55976; wu:fa11h08
Summary
Predicted to enable DNA replication origin binding activity. Acts upstream of or within several processes, including chordate embryonic development; cilium assembly; and response to yeast. Predicted to be located in nucleus. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in proliferative region and tail bud. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See orc1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (33931736..33947874)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (33947050..33963189)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member A1b (aldehyde reductase) Neighboring gene pre-mRNA processing factor 38A Neighboring gene MPL proto-oncogene, thrombopoietin receptor Neighboring gene lnc RNA tyrosine kinase with immunoglobulin-like and EGF-like domains 1, antisense Neighboring gene tyrosine kinase with immunoglobulin-like and EGF-like domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Bicknell LS, et al. Nat Genet, 2011 Feb 27. PMID 21358633
  2. Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors. Maerz LD, et al. Eur J Hum Genet, 2019 May. PMID 30696958, Free PMC Article
  3. The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Kuo AJ, et al. Nature, 2012 Mar 7. PMID 22398447, Free PMC Article
  4. Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Zheng M, et al. Sci Rep, 2018 May 24. PMID 29795396, Free PMC Article
  5. Oxidative stress, cell cycle arrest, DNA damage and apoptosis in adult zebrafish (Danio rerio) induced by tris(1,3-dichloro-2-propyl) phosphate. Chen H, et al. Aquat Toxicol, 2018 Jan. PMID 29149642

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC55976

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199933.1 → NP_956227.1  origin recognition complex subunit 1

    See identical proteins and their annotated locations for NP_956227.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047200
    UniProtKB/TrEMBL
    Q7ZYW6
    Related
    ENSDARP00000126330.1, ENSDART00000151213.3
    Conserved Domains (4) summary
    cd08768
    Location:820 → 903
    Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
    smart00382
    Location:575 → 725
    AAA; ATPases associated with a variety of cellular activities
    cd04719
    Location:45 → 166
    BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
    pfam00004
    Location:579 → 724
    AAA; ATPase family associated with various cellular activities (AAA)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    33931736..33947874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166281.5 → XP_005166338.1  origin recognition complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDS9, F1QLF9
    Related
    ENSDARP00000110729.2, ENSDART00000130492.4
    Conserved Domains (4) summary
    cd08768
    Location:822 → 905
    Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
    smart00382
    Location:577 → 727
    AAA; ATPases associated with a variety of cellular activities
    cd04719
    Location:45 → 168
    BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
    pfam00004
    Location:581 → 726
    AAA; ATPase family associated with various cellular activities (AAA)

  2. XM_021476877.2 → XP_021332552.1  origin recognition complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PM45
    Related
    ENSDARP00000154560.1, ENSDART00000191909.1
    Conserved Domains (3) summary
    cd08768
    Location:783 → 866
    Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
    cd04719
    Location:45 → 168
    BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
    cl26671
    Location:445 → 822
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

  3. XM_068221726.1 → XP_068077827.1  origin recognition complex subunit 1 isoform X3

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395259.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    240662..256824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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