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ephb2b eph receptor B2b [ Danio rerio (zebrafish) ]

Gene ID: 554232, updated on 2-Nov-2024

Summary

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Official Symbol
ephb2bprovided by ZNC
Official Full Name
eph receptor B2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-415
See related
Ensembl:ENSDARG00000021539 AllianceGenome:ZFIN:ZDB-GENE-050522-415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tpx2; fi18g12; wu:fb09e10; wu:fc64a03; wu:fi18g12; zgc:112296
Summary
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to act upstream of or within cell surface receptor protein tyrosine kinase signaling pathway and protein phosphorylation. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in diencephalon and optic stalk. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EPHB2 (EPH receptor B2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See ephb2b in Genome Data Viewer
Location:
chromosome: 11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (28218141..28424181)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (27970967..28177007)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene neuromedin U receptor 3 Neighboring gene lactamase, beta-like 1b Neighboring gene leucine rich repeat containing 38b Neighboring gene leucine-rich repeat-containing protein 38-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Investigation of alpl expression and Tnap-activity in zebrafish implies conserved functions during skeletal and neuronal development. Ohlebusch B, et al. Sci Rep, 2020 Aug 7. PMID 32770041, Free PMC Article
  2. MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. Wang X, et al. Cardiovasc Res, 2016 May 1. PMID 26825552
  3. Toxicity of triphenyltin on the development of retinal axons in zebrafish at low dose. Xiao Y, et al. Aquat Toxicol, 2017 Aug. PMID 28558289
  4. Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Krueger J, et al. Development, 2011 May. PMID 21521739, Free PMC Article
  5. DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. Liu X, et al. J Hematol Oncol, 2015 Feb 22. PMID 25886310, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112296

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ephrin type-B receptor 2b
Names
TPX2, microtubule-associated, homolog
NP_001314672.1
XP_021335297.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327743.1 → NP_001314672.1  ephrin type-B receptor 2b precursor

    Status: VALIDATED

    Source sequence(s)
    CR450786, CR846088
    UniProtKB/TrEMBL
    A0A8M1P981, A2CEJ3
    Related
    ENSDARP00000043755.7, ENSDART00000043756.9

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    28218141..28424181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479622.2 → XP_021335297.1  ephrin type-B receptor 2b isoform X1

    UniProtKB/TrEMBL
    A0A8M9PUX4
    Conserved Domains (5) summary
    cd05065
    Location:619 → 887
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd10477
    Location:17 → 199
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:440 → 523
    fn3; Fibronectin type III domain
    pfam14575
    Location:551 → 619
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl15755
    Location:892 → 931
    SAM_superfamily; SAM (Sterile alpha motif )

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033094.1: Suppressed sequence

    Description
    NM_001033094.1: This RefSeq was removed because it was based on a chimeric sequence.
Nucleotide Protein Strain
Heading Accession and Version

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