atp5fa1 ATP synthase F1 subunit alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp5fa1provided by ZNC
Official Full Name: ATP synthase F1 subunit alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060201-1
See related: Ensembl:ENSDARG00000010149 AllianceGenome:ZFIN:ZDB-GENE-060201-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: atp5a1; zgc:154103
Summary: Enables lipoteichoic acid binding activity. Acts upstream of or within with a positive effect on defense response to bacterium. Predicted to be located in membrane. Predicted to be part of proton-transporting ATP synthase complex, catalytic core F(1). Is expressed in several structures, including digestive system; fin; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22; mitochondrial complex V (ATP synthase) deficiency nuclear type 4A; and mitochondrial complex V (ATP synthase) deficiency nuclear type 4B. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (5080822..5092540)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (4916257..4927975)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenyl ribonucleotide binding	IEA Inferred from Electronic Annotation more info
enables lipoteichoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ATP metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP synthase subunit alpha, mitochondrial

Names: ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; mitochondrial ATP synthase alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077355.1 → NP_001070823.1 ATP synthase subunit alpha, mitochondrial

See identical proteins and their annotated locations for NP_001070823.1

Status: PROVISIONAL

Source sequence(s)

BC124811

UniProtKB/TrEMBL

A0A8M1NBR4, Q08BA1

Related

ENSDARP00000027947.7, ENSDART00000024199.8

Conserved Domains (4) summary

PRK09281
Location:48 → 550

PRK09281; F0F1 ATP synthase subunit alpha; Validated

cd01132
Location:136 → 417

F1_ATPase_alpha; F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to ...

pfam00306
Location:426 → 530

ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain

pfam02874
Location:68 → 134

ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain