homer2 homer scaffold protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: homer2provided by ZNC
Official Full Name: homer scaffold protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-417
See related: AllianceGenome:ZFIN:ZDB-GENE-050522-417
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:111960; zmp:0000000677
Summary: Predicted to enable G protein-coupled glutamate receptor binding activity. Acts upstream of or within olfactory nerve formation and olfactory placode morphogenesis. Predicted to be located in cytoplasm and postsynaptic density. Is expressed in musculature system; periderm; and somite. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (1..3532)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (1..3532)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and in vivo functional investigation of a HOMER2 nonstop variant causing hearing loss.
Title: Identification and in vivo functional investigation of a HOMER2 nonstop variant causing hearing loss.

Submit: New GeneRIF Correction

General gene information

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Markers

G45105 (e-PCR)
- UniSTS:105907

z11608 (e-PCR), detects polymorphism
- UniSTS:205290

fk56e12.x1 (e-PCR)
- UniSTS:201209

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled glutamate receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within olfactory nerve formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory placode morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homer protein homolog 2

Names: homer homolog 2; homer scaffolding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020634.1 → NP_001018470.1 homer protein homolog 2

See identical proteins and their annotated locations for NP_001018470.1

Status: PROVISIONAL

Source sequence(s)

BC095619

UniProtKB/TrEMBL

Q502P2

Conserved Domains (2) summary

cd01206
Location:3 → 111

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

cl03075
Location:180 → 235

GrpE; nucleotide exchange factor GrpE