alox5b.3 arachidonate 5-lipoxygenase b, tandem duplicate 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: alox5b.3provided by ZNC
Official Full Name: arachidonate 5-lipoxygenase b, tandem duplicate 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-330
See related: Ensembl:ENSDARG00000069966 AllianceGenome:ZFIN:ZDB-GENE-050522-330
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb171; sb:cb171; zgc:110251
Summary: Predicted to enable arachidonate 5-lipoxygenase activity. Predicted to be involved in arachidonate metabolic process; lipid oxidation; and lipoxygenase pathway. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nuclear envelope. Is expressed in EVL; head; and periderm. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (592253..617809, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (631450..643548, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables arachidonate 5-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid oxidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid oxidation	IEA Inferred from Electronic Annotation more info
involved_in lipoxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: arachidonate 5-lipoxygenase b, tandem duplicate 3

Names: ALOX3c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020578.1 → NP_001018414.1 arachidonate 5-lipoxygenase b, tandem duplicate 3

See identical proteins and their annotated locations for NP_001018414.1

Status: PROVISIONAL

Source sequence(s)

BC095211

UniProtKB/TrEMBL

Q503R7

Related

ENSDARP00000093033.2, ENSDART00000102257.4

Conserved Domains (2) summary

pfam00305
Location:226 → 667

Lipoxygenase; Lipoxygenase

cl00011
Location:3 → 115

PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...