fabp4b fatty acid binding protein 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fabp4bprovided by ZNC
Official Full Name: fatty acid binding protein 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-391
See related: Ensembl:ENSDARG00000002311 AllianceGenome:ZFIN:ZDB-GENE-050522-391
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fabp11b; fabp11l; zgc:110029
Summary: Predicted to enable fatty acid binding activity. Acts upstream of or within response to prostaglandin and response to vitamin B3. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; eye; heart; ovary; and presumptive retinal pigmented epithelium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1G. Orthologous to several human genes including FABP12 (fatty acid binding protein 12); FABP4 (fatty acid binding protein 4); and FABP5 (fatty acid binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (16148765..16152196, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (16240788..16244219, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

describe the regulation at the duplicated zebrafish fabp7a/fabp7b, fabp10a/fabp10b and fabp11a/fabp11b gene promoters.
Title: Differential regulation of the duplicated fabp7, fabp10 and fabp11 genes of zebrafish by peroxisome proliferator activated receptors.
Phylogenetic analysis and conserved gene synteny of zebrafish fabp11b and fabp11a with tetrapod genes indicated that the emergence of two copies of fabp11 in the zebrafish genome may have resulted from a fish-specific whole genome duplication event.
Title: The evolutionary relationship between the duplicated copies of the zebrafish fabp11 gene and the tetrapod FABP4, FABP5, FABP8 and FABP9 genes.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to prostaglandin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to vitamin B3	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fatty acid binding protein 4b

Names: adipocyte fatty acid-binding protein; fatty acid binding protein 11 like; fatty acid binding protein 11b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.