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mgmt O-6-methylguanine-DNA methyltransferase [ Danio rerio (zebrafish) ]

Gene ID: 553368, updated on 18-Sep-2024

Summary

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Official Symbol
mgmtprovided by ZNC
Official Full Name
O-6-methylguanine-DNA methyltransferaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120614-1
See related
Ensembl:ENSDARG00000043275 AllianceGenome:ZFIN:ZDB-GENE-120614-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable methylated-DNA-[protein]-cysteine S-methyltransferase activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within cellular response to DNA damage stimulus and methylation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; nervous system cancer (multiple); and urinary bladder cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mgmt in Genome Data Viewer
Location:
chromosome: 17
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (20214215..20218391, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (20194379..20198555, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene si:ch211-248a14.8 Neighboring gene ecdysoneless homolog (Drosophila) Neighboring gene gonadotropin-releasing hormone 3 Neighboring gene EBF transcription factor 3b Neighboring gene BCL2 interacting protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Associations Between Behavioral Effects of Bisphenol A and DNA Methylation in Zebrafish Embryos. Olsvik PA, et al. Front Genet, 2019. PMID 30906313, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
methylated-DNA--protein-cysteine methyltransferase
NP_001243172.1
NP_001243173.1
NP_001243174.1
NP_001243175.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256243.1 → NP_001243172.1  methylated-DNA--protein-cysteine methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001243172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BX005375
    UniProtKB/TrEMBL
    A0A8M1NYZ8, F1R3V2
    Related
    ENSDARP00000129345.1, ENSDART00000156540.3
    Conserved Domains (3) summary
    cd06445
    Location:97 → 178
    ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...
    PRK00901
    Location:16 → 178
    PRK00901; methylated-DNA--protein-cysteine methyltransferase; Provisional
    pfam02870
    Location:13 → 93
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

  2. NM_001256244.1 → NP_001243173.1  methylated-DNA--protein-cysteine methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001243173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BX005375
    UniProtKB/TrEMBL
    A0A8M1NYZ8, F1R3V2
    Related
    ENSDARP00000063522.4, ENSDART00000063523.6
    Conserved Domains (3) summary
    cd06445
    Location:97 → 178
    ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...
    PRK00901
    Location:16 → 178
    PRK00901; methylated-DNA--protein-cysteine methyltransferase; Provisional
    pfam02870
    Location:13 → 93
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

  3. NM_001256245.1 → NP_001243174.1  methylated-DNA--protein-cysteine methyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001243174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    BX005375
    UniProtKB/TrEMBL
    A0A8M1P3G0, X1WB89
    Related
    ENSDARP00000129855.1, ENSDART00000155990.3
    Conserved Domains (3) summary
    cd06445
    Location:92 → 173
    ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...
    COG0350
    Location:16 → 174
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    pfam02870
    Location:13 → 88
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

  4. NM_001256246.1 → NP_001243175.1  methylated-DNA--protein-cysteine methyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001243175.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    BX005375
    UniProtKB/TrEMBL
    A0A8M1P3G0, X1WB89
    Related
    ENSDARP00000127480.1, ENSDART00000155632.3
    Conserved Domains (3) summary
    cd06445
    Location:92 → 173
    ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...
    COG0350
    Location:16 → 174
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    pfam02870
    Location:13 → 88
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    20214215..20218391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394981.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    196662..200892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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