slc18a2 solute carrier family 18 member 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc18a2provided by ZNC
Official Full Name: solute carrier family 18 member 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-080514-1
See related: Ensembl:ENSDARG00000015110 AllianceGenome:ZFIN:ZDB-GENE-080514-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable serotonin:sodium:chloride symporter activity. Acts upstream of or within several processes, including startle response; swimming behavior; and thigmotaxis. Predicted to be located in membrane. Predicted to be active in synaptic vesicle membrane and terminal bouton. Is expressed in brain and neurons. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in Parkinson's disease; infantile parkinsonism-dystonia 2; and type 1 diabetes mellitus. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (23782324..23811312)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (23762300..23791288)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Motility phenotype in a zebrafish vmat2 mutant.
Title: Motility phenotype in a zebrafish vmat2 mutant.
Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish.
Title: Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish.
Taken together, these findings suggest that Vmat2 heterzygous mutant zebrafish may serve as a new model of anxiety, which may be related with the low level of DA, 5-HT and NE.
Title: Vesicular monoamine transporter 2 (Vmat2) knockdown elicits anxiety-like behavior in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables serotonin:sodium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurotransmitter transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sleep	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thigmotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xenobiotic transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: synaptic vesicular amine transporter

Names: solute carrier family 18 (vesicular monoamine transporter), member 2; solute carrier family 18 (vesicular monoamine), member 2; vmat2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256225.2 → NP_001243154.1 synaptic vesicular amine transporter

Status: PROVISIONAL

Source sequence(s)

BC090766

UniProtKB/TrEMBL

A0A8M1P3E9, Q5CZP4

Related

ENSDARP00000023268.8, ENSDART00000025466.9

Conserved Domains (3) summary

cd06174
Location:295 → 472

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00880
Location:133 → 274

2_A_01_02; Multidrug resistance protein

pfam07690
Location:132 → 438

MFS_1; Major Facilitator Superfamily