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SETD5 SET domain containing 5 [ Homo sapiens (human) ]

Gene ID: 55209, updated on 2-Nov-2024

Summary

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Official Symbol
SETD5provided by HGNC
Official Full Name
SET domain containing 5provided by HGNC
Primary source
HGNC:HGNC:25566
See related
Ensembl:ENSG00000168137 MIM:615743; AllianceGenome:HGNC:25566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRD23; SETD5A
Summary
This function of this gene has yet to be determined but based on sequence similarity to other SET domain proteins it may function as a histone methyltransferase. Mutations in this gene have been associated with an autosomal dominant form of intellectual disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in brain (RPKM 9.1), thyroid (RPKM 9.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See SETD5 in Genome Data Viewer
Location:
3p25.3
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (9397615..9478154)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (9389553..9470070)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9439299..9519838)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SLIT-ROBO Rho GTPase activating protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19402 Neighboring gene phosphoglycerate mutase 1 pseudogene 4 Neighboring gene THUMPD3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19403 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:9444537-9445037 Neighboring gene Sharpr-MPRA regulatory region 11896 Neighboring gene THUMP domain containing 3 Neighboring gene MPRA-validated peak4533 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9543010-9543735 Neighboring gene Sharpr-MPRA regulatory region 15302 Neighboring gene LHFPL tetraspan subfamily member 4 Neighboring gene uncharacterized LOC105376949

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non-small cell lung cancer patients. Yu H, et al. BMC Cancer, 2019 Jul 25. PMID 31345185, Free PMC Article
  2. Structure, activity and function of the lysine methyltransferase SETD5. Li M, et al. Front Endocrinol (Lausanne), 2023. PMID 36875494, Free PMC Article
  3. Genetic variations on SETD5 underlying autistic conditions. Fernandes IR, et al. Dev Neurobiol, 2018 May. PMID 29484850
  4. De novo loss-of-function mutations in SETD5, encoding a methyltransferase in a 3p25 microdeletion syndrome critical region, cause intellectual disability. Grozeva D, et al. Am J Hum Genet, 2014 Apr 3. PMID 24680889, Free PMC Article
  5. Expansion and further delineation of the SETD5 phenotype leading to global developmental delay, variable dysmorphic features, and reduced penetrance. Powis Z, et al. Clin Genet, 2018 Apr. PMID 28881385

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SETD5 haploinsufficiency affects mitochondrial compartment in neural cells.
    Title: SETD5 haploinsufficiency affects mitochondrial compartment in neural cells.
  2. Structure, activity and function of the lysine methyltransferase SETD5.
    Title: Structure, activity and function of the lysine methyltransferase SETD5.
  3. SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth.
    Title: SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth.
  4. SET Domain-Containing Protein 5 Enhances the Cell Stemness of Non-Small Cell Lung Cancer via the PI3K/Akt/mTOR Pathway.
    Title: SET Domain-Containing Protein 5 Enhances the Cell Stemness of Non-Small Cell Lung Cancer via the PI3K/Akt/mTOR Pathway.
  5. The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.
    Title: The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.
  6. Su(var)3-9, Enhancer of Zeste, and Trithorax Domain-Containing 5 Facilitates Tumor Growth and Pulmonary Metastasis through Up-Regulation of AKT1 Signaling in Breast Cancer.
    Title: Su(var)3-9, Enhancer of Zeste, and Trithorax Domain-Containing 5 Facilitates Tumor Growth and Pulmonary Metastasis through Up-Regulation of AKT1 Signaling in Breast Cancer.
  7. SET domain-containing 5 is a potential prognostic biomarker that promotes esophageal squamous cell carcinoma stemness.
    Title: SET domain-containing 5 is a potential prognostic biomarker that promotes esophageal squamous cell carcinoma stemness.
  8. Study results suggest that SETD5 could regulate p-P90RSK and facilitate the migration and invasion of non-small cell lung cancer (NSCLC) and may be related to the poor prognosis of patients with NSCLC.
    Title: SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non-small cell lung cancer patients.
  9. We suggest that the phenotype of SETD5 is more complex and variable than previously presented. Therefore, many features and presentations need to be considered when evaluating a patient for SETD5 alterations through Diagnostic exome sequencing .
    Title: Expansion and further delineation of the SETD5 phenotype leading to global developmental delay, variable dysmorphic features, and reduced penetrance.
  10. These co-occurring hits involved known disease-associated genes such as SETD5, AUTS2, and NRXN1, and were enriched for cellular and developmental processes. Accurate genetic diagnosis of complex disorders will require complete evaluation of the genetic background even after a candidate disease-associated variant is identified
    Title: Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease-associated variants.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual disability-facial dysmorphism syndrome due to SETD5 haploinsufficiency
MedGen: C3810406 OMIM: 615761 GeneReviews: Not available
not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2014-11-06)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2014-11-06)

ClinGen Genome Curation PagePubMed

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10707, KIAA1757, DKFZp686J18276

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H3K36 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3K36 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3K9 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9me2 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in cognition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Rpd3L-Expanded complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in euchromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase SETD5
Names
SET domain-containing protein 5
NP_001073986.1
NP_001278972.1
NP_001336380.1
XP_005265358.1
XP_011532224.1
XP_011532230.1
XP_011532235.1
XP_016862260.1
XP_016862263.1
XP_047304422.1
XP_047304423.1
XP_047304424.1
XP_047304425.1
XP_047304426.1
XP_047304427.1
XP_047304428.1
XP_047304429.1
XP_047304430.1
XP_047304431.1
XP_047304432.1
XP_047304433.1
XP_047304434.1
XP_047304435.1
XP_047304436.1
XP_047304437.1
XP_047304438.1
XP_047304439.1
XP_047304440.1
XP_047304441.1
XP_047304442.1
XP_047304443.1
XP_047304444.1
XP_047304445.1
XP_047304446.1
XP_047304447.1
XP_047304448.1
XP_047304449.1
XP_047304450.1
XP_047304451.1
XP_047304452.1
XP_047304453.1
XP_047304454.1
XP_047304455.1
XP_047304456.1
XP_047304457.1
XP_047304458.1
XP_047304459.1
XP_047304460.1
XP_047304461.1
XP_047304462.1
XP_047304463.1
XP_047304464.1
XP_054203082.1
XP_054203083.1
XP_054203084.1
XP_054203085.1
XP_054203086.1
XP_054203087.1
XP_054203088.1
XP_054203089.1
XP_054203090.1
XP_054203091.1
XP_054203092.1
XP_054203093.1
XP_054203094.1
XP_054203095.1
XP_054203096.1
XP_054203097.1
XP_054203098.1
XP_054203099.1
XP_054203100.1
XP_054203101.1
XP_054203102.1
XP_054203103.1
XP_054203104.1
XP_054203105.1
XP_054203106.1
XP_054203107.1
XP_054203108.1
XP_054203109.1
XP_054203110.1
XP_054203111.1
XP_054203112.1
XP_054203113.1
XP_054203114.1
XP_054203115.1
XP_054203116.1
XP_054203117.1
XP_054203118.1
XP_054203119.1
XP_054203120.1
XP_054203121.1
XP_054203122.1
XP_054203123.1
XP_054203124.1
XP_054203125.1
XP_054203126.1
XP_054203127.1
XP_054203128.1
XP_054203129.1
XP_054203130.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034132.1 RefSeqGene

    Range
    4916..85455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080517.3 → NP_001073986.1  histone-lysine N-methyltransferase SETD5 isoform 1

    See identical proteins and their annotated locations for NP_001073986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB051544, AC018506, AI243838, AK092046, CR627408
    Consensus CDS
    CCDS46741.1
    UniProtKB/Swiss-Prot
    Q6AI17, Q8WUB6, Q9C0A6, Q9H3X4, Q9H6V7, Q9H7S3, Q9NVI9
    UniProtKB/TrEMBL
    B3KRD6
    Related
    ENSP00000385852.2, ENST00000402198.7
    Conserved Domains (1) summary
    smart00317
    Location:286 → 395
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

  2. NM_001292043.2 → NP_001278972.1  histone-lysine N-methyltransferase SETD5 isoform 2

    See identical proteins and their annotated locations for NP_001278972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon structure and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AB051544, AC018506, AI243838, AK092046, AW021954, CR627408, DB275141
    UniProtKB/TrEMBL
    B3KRD6
    Conserved Domains (2) summary
    smart00317
    Location:188 → 297
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cl27032
    Location:336 → 556
    Utp14; Utp14 protein

  3. NM_001349451.2 → NP_001336380.1  histone-lysine N-methyltransferase SETD5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon structure and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AC018506
    UniProtKB/TrEMBL
    B3KRD6
    Conserved Domains (2) summary
    smart00317
    Location:188 → 297
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cl27032
    Location:336 → 556
    Utp14; Utp14 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    9397615..9478154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448468.1 → XP_047304424.1  histone-lysine N-methyltransferase SETD5 isoform X1

  2. XM_047448473.1 → XP_047304429.1  histone-lysine N-methyltransferase SETD5 isoform X2

  3. XM_047448482.1 → XP_047304438.1  histone-lysine N-methyltransferase SETD5 isoform X7

    UniProtKB/TrEMBL
    A0A804HKJ9

  4. XM_047448487.1 → XP_047304443.1  histone-lysine N-methyltransferase SETD5 isoform X12

    UniProtKB/TrEMBL
    E7EWN3

  5. XM_047448489.1 → XP_047304445.1  histone-lysine N-methyltransferase SETD5 isoform X13

  6. XM_047448496.1 → XP_047304452.1  histone-lysine N-methyltransferase SETD5 isoform X18

    UniProtKB/Swiss-Prot
    Q6AI17, Q8WUB6, Q9C0A6, Q9H3X4, Q9H6V7, Q9H7S3, Q9NVI9

  7. XM_047448474.1 → XP_047304430.1  histone-lysine N-methyltransferase SETD5 isoform X2

  8. XM_047448481.1 → XP_047304437.1  histone-lysine N-methyltransferase SETD5 isoform X7

    UniProtKB/TrEMBL
    A0A804HKJ9

  9. XM_047448479.1 → XP_047304435.1  histone-lysine N-methyltransferase SETD5 isoform X6

  10. XM_047448488.1 → XP_047304444.1  histone-lysine N-methyltransferase SETD5 isoform X12

    UniProtKB/TrEMBL
    E7EWN3

  11. XM_047448490.1 → XP_047304446.1  histone-lysine N-methyltransferase SETD5 isoform X13

  12. XM_047448497.1 → XP_047304453.1  histone-lysine N-methyltransferase SETD5 isoform X18

    UniProtKB/Swiss-Prot
    Q6AI17, Q8WUB6, Q9C0A6, Q9H3X4, Q9H6V7, Q9H7S3, Q9NVI9

  13. XM_047448466.1 → XP_047304422.1  histone-lysine N-methyltransferase SETD5 isoform X1

  14. XM_047448477.1 → XP_047304433.1  histone-lysine N-methyltransferase SETD5 isoform X4

  15. XM_047448483.1 → XP_047304439.1  histone-lysine N-methyltransferase SETD5 isoform X9

  16. XM_047448478.1 → XP_047304434.1  histone-lysine N-methyltransferase SETD5 isoform X5

  17. XM_047448486.1 → XP_047304442.1  histone-lysine N-methyltransferase SETD5 isoform X11

  18. XM_047448485.1 → XP_047304441.1  histone-lysine N-methyltransferase SETD5 isoform X10

  19. XM_047448495.1 → XP_047304451.1  histone-lysine N-methyltransferase SETD5 isoform X17

  20. XM_047448476.1 → XP_047304432.1  histone-lysine N-methyltransferase SETD5 isoform X3

  21. XM_011533922.2 → XP_011532224.1  histone-lysine N-methyltransferase SETD5 isoform X2

    See identical proteins and their annotated locations for XP_011532224.1

    UniProtKB/TrEMBL
    B3KRD6
    Conserved Domains (3) summary
    PLN02217
    Location:1353 → 1460
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    COG5644
    Location:466 → 686
    COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
    cd19181
    Location:298 → 447
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

  22. XM_047448480.1 → XP_047304436.1  histone-lysine N-methyltransferase SETD5 isoform X7

    UniProtKB/TrEMBL
    A0A804HKJ9
    Related
    ENSP00000507956.1, ENST00000682536.1

  23. XM_017006771.2 → XP_016862260.1  histone-lysine N-methyltransferase SETD5 isoform X6

    UniProtKB/TrEMBL
    B3KRD6
    Conserved Domains (3) summary
    PLN02217
    Location:1340 → 1447
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    COG5644
    Location:453 → 673
    COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
    cd19181
    Location:285 → 434
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

  24. XM_005265301.2 → XP_005265358.1  histone-lysine N-methyltransferase SETD5 isoform X12

    UniProtKB/TrEMBL
    B3KRD6, E7EWN3
    Related
    ENSP00000384114.1, ENST00000407969.5
    Conserved Domains (3) summary
    PLN02217
    Location:1321 → 1428
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    COG5644
    Location:453 → 673
    COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
    cd19181
    Location:285 → 434
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

  25. XM_011533928.2 → XP_011532230.1  histone-lysine N-methyltransferase SETD5 isoform X8

    UniProtKB/TrEMBL
    B3KRD6
    Conserved Domains (3) summary
    PLN02217
    Location:1334 → 1441
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    COG5644
    Location:447 → 667
    COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
    cd19181
    Location:279 → 428
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

  26. XM_047448492.1 → XP_047304448.1  histone-lysine N-methyltransferase SETD5 isoform X15

  27. XM_017006774.2 → XP_016862263.1  histone-lysine N-methyltransferase SETD5 isoform X13

    UniProtKB/TrEMBL
    B3KRD6
    Conserved Domains (3) summary
    PLN02217
    Location:1321 → 1428
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    COG5644
    Location:434 → 654
    COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
    cd19181
    Location:266 → 415
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

  28. XM_047448500.1 → XP_047304456.1  histone-lysine N-methyltransferase SETD5 isoform X22

  29. XM_047448501.1 → XP_047304457.1  histone-lysine N-methyltransferase SETD5 isoform X23

  30. XM_047448503.1 → XP_047304459.1  histone-lysine N-methyltransferase SETD5 isoform X25

  31. XM_047448504.1 → XP_047304460.1  histone-lysine N-methyltransferase SETD5 isoform X26

  32. XM_047448502.1 → XP_047304458.1  histone-lysine N-methyltransferase SETD5 isoform X24

  33. XM_047448505.1 → XP_047304461.1  histone-lysine N-methyltransferase SETD5 isoform X27

  34. XM_047448506.1 → XP_047304462.1  histone-lysine N-methyltransferase SETD5 isoform X28

    Related
    ENSP00000507953.1, ENST00000684055.1

  35. XM_047448507.1 → XP_047304463.1  histone-lysine N-methyltransferase SETD5 isoform X29

  36. XM_047448508.1 → XP_047304464.1  histone-lysine N-methyltransferase SETD5 isoform X30

  37. XM_047448491.1 → XP_047304447.1  histone-lysine N-methyltransferase SETD5 isoform X14

  38. XM_047448470.1 → XP_047304426.1  histone-lysine N-methyltransferase SETD5 isoform X1

  39. XM_047448469.1 → XP_047304425.1  histone-lysine N-methyltransferase SETD5 isoform X1

  40. XM_047448484.1 → XP_047304440.1  histone-lysine N-methyltransferase SETD5 isoform X10

  41. XM_047448494.1 → XP_047304450.1  histone-lysine N-methyltransferase SETD5 isoform X16

  42. XM_047448498.1 → XP_047304454.1  histone-lysine N-methyltransferase SETD5 isoform X19

  43. XM_047448472.1 → XP_047304428.1  histone-lysine N-methyltransferase SETD5 isoform X1

  44. XM_047448475.1 → XP_047304431.1  histone-lysine N-methyltransferase SETD5 isoform X2

  45. XM_047448467.1 → XP_047304423.1  histone-lysine N-methyltransferase SETD5 isoform X1

  46. XM_047448493.1 → XP_047304449.1  histone-lysine N-methyltransferase SETD5 isoform X15

  47. XM_047448471.1 → XP_047304427.1  histone-lysine N-methyltransferase SETD5 isoform X1

  48. XM_047448499.1 → XP_047304455.1  histone-lysine N-methyltransferase SETD5 isoform X20

  49. XM_011533933.2 → XP_011532235.1  histone-lysine N-methyltransferase SETD5 isoform X21

    See identical proteins and their annotated locations for XP_011532235.1

    UniProtKB/TrEMBL
    B3KRD6
    Conserved Domains (3) summary
    PLN02217
    Location:1210 → 1317
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    COG5644
    Location:323 → 543
    COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
    cd19181
    Location:155 → 304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    9389553..9470070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347108.1 → XP_054203083.1  histone-lysine N-methyltransferase SETD5 isoform X1

  2. XM_054347114.1 → XP_054203089.1  histone-lysine N-methyltransferase SETD5 isoform X2

  3. XM_054347125.1 → XP_054203100.1  histone-lysine N-methyltransferase SETD5 isoform X7

    UniProtKB/TrEMBL
    A0A804HKJ9

  4. XM_054347115.1 → XP_054203090.1  histone-lysine N-methyltransferase SETD5 isoform X2

  5. XM_054347124.1 → XP_054203099.1  histone-lysine N-methyltransferase SETD5 isoform X7

    UniProtKB/TrEMBL
    A0A804HKJ9

  6. XM_054347121.1 → XP_054203096.1  histone-lysine N-methyltransferase SETD5 isoform X6

  7. XM_054347133.1 → XP_054203108.1  histone-lysine N-methyltransferase SETD5 isoform X12

    UniProtKB/TrEMBL
    E7EWN3

  8. XM_054347135.1 → XP_054203110.1  histone-lysine N-methyltransferase SETD5 isoform X13

  9. XM_054347143.1 → XP_054203118.1  histone-lysine N-methyltransferase SETD5 isoform X18

    UniProtKB/Swiss-Prot
    Q6AI17, Q8WUB6, Q9C0A6, Q9H3X4, Q9H6V7, Q9H7S3, Q9NVI9

  10. XM_054347107.1 → XP_054203082.1  histone-lysine N-methyltransferase SETD5 isoform X1

  11. XM_054347118.1 → XP_054203093.1  histone-lysine N-methyltransferase SETD5 isoform X4

  12. XM_054347127.1 → XP_054203102.1  histone-lysine N-methyltransferase SETD5 isoform X9

  13. XM_054347119.1 → XP_054203094.1  histone-lysine N-methyltransferase SETD5 isoform X5

  14. XM_054347130.1 → XP_054203105.1  histone-lysine N-methyltransferase SETD5 isoform X11

  15. XM_054347129.1 → XP_054203104.1  histone-lysine N-methyltransferase SETD5 isoform X10

  16. XM_054347141.1 → XP_054203116.1  histone-lysine N-methyltransferase SETD5 isoform X17

  17. XM_054347117.1 → XP_054203092.1  histone-lysine N-methyltransferase SETD5 isoform X3

  18. XM_054347113.1 → XP_054203088.1  histone-lysine N-methyltransferase SETD5 isoform X2

  19. XM_054347123.1 → XP_054203098.1  histone-lysine N-methyltransferase SETD5 isoform X7

    UniProtKB/TrEMBL
    A0A804HKJ9

  20. XM_054347120.1 → XP_054203095.1  histone-lysine N-methyltransferase SETD5 isoform X6

  21. XM_054347131.1 → XP_054203106.1  histone-lysine N-methyltransferase SETD5 isoform X12

    UniProtKB/TrEMBL
    E7EWN3

  22. XM_054347126.1 → XP_054203101.1  histone-lysine N-methyltransferase SETD5 isoform X8

  23. XM_054347138.1 → XP_054203113.1  histone-lysine N-methyltransferase SETD5 isoform X15

  24. XM_054347134.1 → XP_054203109.1  histone-lysine N-methyltransferase SETD5 isoform X13

  25. XM_054347147.1 → XP_054203122.1  histone-lysine N-methyltransferase SETD5 isoform X22

  26. XM_054347148.1 → XP_054203123.1  histone-lysine N-methyltransferase SETD5 isoform X23

  27. XM_054347150.1 → XP_054203125.1  histone-lysine N-methyltransferase SETD5 isoform X25

  28. XM_054347151.1 → XP_054203126.1  histone-lysine N-methyltransferase SETD5 isoform X26

  29. XM_054347149.1 → XP_054203124.1  histone-lysine N-methyltransferase SETD5 isoform X24

  30. XM_054347152.1 → XP_054203127.1  histone-lysine N-methyltransferase SETD5 isoform X27

  31. XM_054347153.1 → XP_054203128.1  histone-lysine N-methyltransferase SETD5 isoform X28

  32. XM_054347154.1 → XP_054203129.1  histone-lysine N-methyltransferase SETD5 isoform X29

  33. XM_054347155.1 → XP_054203130.1  histone-lysine N-methyltransferase SETD5 isoform X30

  34. XM_054347116.1 → XP_054203091.1  histone-lysine N-methyltransferase SETD5 isoform X2

  35. XM_054347137.1 → XP_054203112.1  histone-lysine N-methyltransferase SETD5 isoform X14

  36. XM_054347110.1 → XP_054203085.1  histone-lysine N-methyltransferase SETD5 isoform X1

  37. XM_054347109.1 → XP_054203084.1  histone-lysine N-methyltransferase SETD5 isoform X1

  38. XM_054347140.1 → XP_054203115.1  histone-lysine N-methyltransferase SETD5 isoform X16

  39. XM_054347112.1 → XP_054203087.1  histone-lysine N-methyltransferase SETD5 isoform X1

  40. XM_054347122.1 → XP_054203097.1  histone-lysine N-methyltransferase SETD5 isoform X6

  41. XM_054347139.1 → XP_054203114.1  histone-lysine N-methyltransferase SETD5 isoform X15

  42. XM_054347136.1 → XP_054203111.1  histone-lysine N-methyltransferase SETD5 isoform X13

  43. XM_054347128.1 → XP_054203103.1  histone-lysine N-methyltransferase SETD5 isoform X10

  44. XM_054347132.1 → XP_054203107.1  histone-lysine N-methyltransferase SETD5 isoform X12

    UniProtKB/TrEMBL
    E7EWN3

  45. XM_054347142.1 → XP_054203117.1  histone-lysine N-methyltransferase SETD5 isoform X18

    UniProtKB/Swiss-Prot
    Q6AI17, Q8WUB6, Q9C0A6, Q9H3X4, Q9H6V7, Q9H7S3, Q9NVI9

  46. XM_054347144.1 → XP_054203119.1  histone-lysine N-methyltransferase SETD5 isoform X19

  47. XM_054347111.1 → XP_054203086.1  histone-lysine N-methyltransferase SETD5 isoform X1

  48. XM_054347145.1 → XP_054203120.1  histone-lysine N-methyltransferase SETD5 isoform X20

  49. XM_054347146.1 → XP_054203121.1  histone-lysine N-methyltransferase SETD5 isoform X21

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018187.2: Suppressed sequence

    Description
    NM_018187.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C0A6.2 GenPept UniProtKB/Swiss-Prot:Q9C0A6

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