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PPP2R2A protein phosphatase 2 regulatory subunit Balpha [ Homo sapiens (human) ]

Gene ID: 5520, updated on 14-Nov-2024

Summary

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Official Symbol
PPP2R2Aprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit Balphaprovided by HGNC
Primary source
HGNC:HGNC:9304
See related
Ensembl:ENSG00000221914 MIM:604941; AllianceGenome:HGNC:9304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B55A; PR52A; PR55A; B55ALPHA; PR55alpha
Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in esophagus (RPKM 15.8), placenta (RPKM 12.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See PPP2R2A in Genome Data Viewer
Location:
8p21.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (26291508..26372680)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (26567415..26649239)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26149024..26230196)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379336 Neighboring gene MPRA-validated peak6960 silencer Neighboring gene RNA, 5S ribosomal pseudogene 258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:26008986-26009594 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:26035468-26035634 Neighboring gene MPRA-validated peak6961 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19037 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:26087585-26088201 Neighboring gene matrix metallopeptidase 12 (macrophage elastase) pseudogene Neighboring gene Sharpr-MPRA regulatory region 858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19038 Neighboring gene Sharpr-MPRA regulatory region 13890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:26192157-26192656 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:26239047-26240246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19039 Neighboring gene Sharpr-MPRA regulatory region 12075 Neighboring gene GATA motif-containing MPRA enhancer 260 Neighboring gene SDA1 domain containing 1 pseudogene 1 Neighboring gene BCL2 interacting protein 3 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. Ruvolo PP, et al. Biochim Biophys Acta, 2014 Sep. PMID 24858343, Free PMC Article
  2. miR-892a regulated PPP2R2A expression and promoted cell proliferation of human colorectal cancer cells. Liang WL, et al. Biomed Pharmacother, 2015 May. PMID 26054685
  3. PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus. Vogelsberg-Ragaglia V, et al. Exp Neurol, 2001 Apr. PMID 11259128
  4. Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study. Cheng Y, et al. Cancer Genet, 2011 Jul. PMID 21872824, Free PMC Article
  5. Protein phosphatase 2A regulatory subunit B55α functions in mouse oocyte maturation and early embryonic development. Liang S, et al. Oncotarget, 2017 Apr 18. PMID 28439046, Free PMC Article

See all (241) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55alpha/PP2A through helical motifs.
    Title: FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs.
  2. PR55alpha-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by gamma-irradiation.
    Title: PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation.
  3. PP2A-B55alpha controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminus.
    Title: PP2A-B55alpha controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminus.
  4. PP2A/B55alpha substrate recruitment as defined by the retinoblastoma-related protein p107.
    Title: PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107.
  5. LncRNA-HCG18 regulates the viability, apoptosis, migration, invasion and epithelial-mesenchymal transition of papillary thyroid cancer cells via regulating the miR-106a-5p/PPP2R2A axis.
    Title: LncRNA-HCG18 regulates the viability, apoptosis, migration, invasion and epithelial-mesenchymal transition of papillary thyroid cancer cells via regulating the miR-106a-5p/PPP2R2A axis.
  6. B55alpha/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels?
    Title: B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels?
  7. AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.
    Title: AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.
  8. microRNA-665 is down-regulated in gastric cancer and inhibits proliferation, invasion, and EMT by targeting PPP2R2A.
    Title: microRNA-665 is down-regulated in gastric cancer and inhibits proliferation, invasion, and EMT by targeting PPP2R2A.
  9. 14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation.
    Title: 14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation.
  10. Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B.
    Title: Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of protein phosphatase 2, regulatory subunit B, alpha (PPP2R2A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, protein phosphatase 2, regulatory subunit B, alpha (PPP2R2A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26613, FLJ41727, MGC52248, DKFZp686N05117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase regulator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to morphine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Names
protein phosphatase 2, regulatory subunit B, alpha
NP_001171062.1
NP_002708.1
XP_005273616.1
XP_011542867.1
XP_024302954.1
XP_024302955.1
XP_047277889.1
XP_047277890.1
XP_047277891.1
XP_047277892.1
XP_054216733.1
XP_054216734.1
XP_054216735.1
XP_054216736.1
XP_054216737.1
XP_054216738.1
XP_054216739.1
XP_054216740.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177591.2 → NP_001171062.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2

    See identical proteins and their annotated locations for NP_001171062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC022911, AI814790, AK303981, BC041071
    Consensus CDS
    CCDS55213.1
    UniProtKB/TrEMBL
    Q56VW8
    Related
    ENSP00000325074.7, ENST00000315985.7
    Conserved Domains (2) summary
    COG5170
    Location:17 → 452
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:41 → 89
    7WD40; WD40 repeat [structural motif]

  2. NM_002717.4 → NP_002708.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1

    See identical proteins and their annotated locations for NP_002708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC022911, AI814790, AK314823, BC041071, DB451813
    Consensus CDS
    CCDS34867.1
    UniProtKB/Swiss-Prot
    B2RBU8, B4E1T7, P50409, P63151, Q00007
    UniProtKB/TrEMBL
    A0A140VJT0, Q56VW8
    Related
    ENSP00000370113.3, ENST00000380737.8
    Conserved Domains (2) summary
    COG5170
    Location:7 → 442
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:31 → 79
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    26291508..26372680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273559.2 → XP_005273616.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2

    See identical proteins and their annotated locations for XP_005273616.1

    UniProtKB/TrEMBL
    Q56VW8
    Conserved Domains (2) summary
    COG5170
    Location:7 → 441
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:30 → 78
    7WD40; WD40 repeat [structural motif]

  2. XM_011544565.2 → XP_011542867.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1

    See identical proteins and their annotated locations for XP_011542867.1

    UniProtKB/TrEMBL
    Q56VW8
    Conserved Domains (2) summary
    COG5170
    Location:17 → 451
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:40 → 88
    7WD40; WD40 repeat [structural motif]

  3. XM_047421936.1 → XP_047277892.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X5

  4. XM_024447186.2 → XP_024302954.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3

    UniProtKB/TrEMBL
    Q56VW8
    Conserved Domains (2) summary
    COG5170
    Location:5 → 422
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:11 → 59
    7WD40; WD40 repeat [structural motif]

  5. XM_024447187.2 → XP_024302955.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    UniProtKB/TrEMBL
    A0A590UJJ1, A0A590UJY3
    Related
    ENSP00000499441.1, ENST00000660435.1
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  6. XM_047421935.1 → XP_047277891.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    UniProtKB/TrEMBL
    A0A590UJJ1

  7. XM_047421933.1 → XP_047277889.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    UniProtKB/TrEMBL
    A0A590UJJ1

  8. XM_047421934.1 → XP_047277890.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    UniProtKB/TrEMBL
    A0A590UJJ1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    26567415..26649239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360759.1 → XP_054216734.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2

  2. XM_054360761.1 → XP_054216736.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    UniProtKB/TrEMBL
    A0A590UJJ1

  3. XM_054360758.1 → XP_054216733.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1

  4. XM_054360765.1 → XP_054216740.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X5

  5. XM_054360764.1 → XP_054216739.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    UniProtKB/TrEMBL
    A0A590UJJ1

  6. XM_054360762.1 → XP_054216737.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    UniProtKB/TrEMBL
    A0A590UJJ1

  7. XM_054360760.1 → XP_054216735.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3

  8. XM_054360763.1 → XP_054216738.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    UniProtKB/TrEMBL
    A0A590UJJ1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63151.1 GenPept UniProtKB/Swiss-Prot:P63151

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