U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CEP55 centrosomal protein 55 [ Homo sapiens (human) ]

Gene ID: 55165, updated on 12-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
CEP55provided by HGNC
Official Full Name
centrosomal protein 55provided by HGNC
Primary source
HGNC:HGNC:1161
See related
Ensembl:ENSG00000138180 MIM:610000; AllianceGenome:HGNC:1161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT111; MARCH; URCC6; C10orf3
Summary
Enables identical protein binding activity. Involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Acts upstream of or within mitotic cytokinesis. Located in Flemming body and centrosome. Implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 13.8), lymph node (RPKM 8.3) and 14 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CEP55 in Genome Data Viewer
Location:
10q23.33
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (93496612..93529092)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (94376610..94409086)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95256369..95288849)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:95048576-95049775 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:95049831-95050331 Neighboring gene ribosomal protein L17 pseudogene 34 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:95093669-95094868 Neighboring gene myoferlin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:95143327-95143828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:95143829-95144328 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:95166463-95166962 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:95195537-95196098 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:95196661-95197860 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:95219557-95220179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:95229071-95229920 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2628 Neighboring gene Sharpr-MPRA regulatory region 3496 Neighboring gene RNA, 5S ribosomal pseudogene 323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:95315968-95316468 Neighboring gene uncharacterized LOC105378436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:95325824-95326662 Neighboring gene uncharacterized LOC124902485 Neighboring gene free fatty acid receptor 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. Kalimutho M, et al. EMBO Mol Med, 2018 Sep. PMID 30108112, Free PMC Article
  2. Lentivirus-mediated knockdown of CEP55 suppresses cell proliferation of breast cancer cells. Wang Y, et al. Biosci Trends, 2016 Feb. PMID 26902787
  3. Upregulation of centrosomal protein 55 is associated with unfavorable prognosis and tumor invasion in epithelial ovarian carcinoma. Zhang W, et al. Tumour Biol, 2016 May. PMID 26615423, Free PMC Article
  4. Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancer. Chen CH, et al. Mol Cancer, 2015 Apr 12. PMID 25889801, Free PMC Article
  5. A nonsense mutation in CEP55 defines a new locus for a Meckel-like syndrome, an autosomal recessive lethal fetal ciliopathy. Bondeson ML, et al. Clin Genet, 2017 Nov. PMID 28295209

See all (171) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SPI1-mediated transcriptional activation of CEP55 promotes the malignant growth of triple-negative breast cancer and M2 macrophage polarization.
    Title: SPI1-mediated transcriptional activation of CEP55 promotes the malignant growth of triple-negative breast cancer and M2 macrophage polarization.
  2. Centrosomal Protein 55 Regulates Chromosomal Instability in Cancer Cells by Controlling Microtubule Dynamics.
    Title: Centrosomal Protein 55 Regulates Chromosomal Instability in Cancer Cells by Controlling Microtubule Dynamics.
  3. CEP55 predicts the poor prognosis and promotes tumorigenesis in endometrial cancer by regulating the Foxo1 signaling.
    Title: CEP55 predicts the poor prognosis and promotes tumorigenesis in endometrial cancer by regulating the Foxo1 signaling.
  4. CEP55 3'-UTR promotes epithelial-mesenchymal transition and enhances tumorigenicity of bladder cancer cells by acting as a ceRNA regulating miR-497-5p.
    Title: CEP55 3'-UTR promotes epithelial-mesenchymal transition and enhances tumorigenicity of bladder cancer cells by acting as a ceRNA regulating miR-497-5p.
  5. The Role of CEP55 Expression in Tumor Immune Response and Prognosis of Patients with Non-small Cell lung Cancer.
    Title: The Role of CEP55 Expression in Tumor Immune Response and Prognosis of Patients with Non-small Cell lung Cancer.
  6. Circ_0136666 aggravates osteosarcoma development through mediating miR-1244/CEP55 axis.
    Title: Circ_0136666 aggravates osteosarcoma development through mediating miR-1244/CEP55 axis.
  7. MicroRNA-148a-3p suppresses cell proliferation and migration of esophageal carcinoma by targeting CEP55.
    Title: MicroRNA-148a-3p suppresses cell proliferation and migration of esophageal carcinoma by targeting CEP55.
  8. Long intergenic non-protein coding RNA 662 accelerates the progression of gastric cancer through up-regulating centrosomal protein 55 by sponging microRNA-195-5p.
    Title: Long intergenic non-protein coding RNA 662 accelerates the progression of gastric cancer through up-regulating centrosomal protein 55 by sponging microRNA-195-5p.
  9. Inhibition of miR-144-3p exacerbates non-small cell lung cancer progression by targeting CEP55.
    Title: Inhibition of miR-144-3p exacerbates non-small cell lung cancer progression by targeting CEP55.
  10. The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma.
    Title: The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma.
Submit: New GeneRIF Correction See all GeneRIFs (63)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome
MedGen: C1856053 OMIM: 236500 GeneReviews: Not available
Compare labs

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ10540

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in midbody abscission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Flemming body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
centrosomal protein of 55 kDa
Names
cancer/testis antigen 111
centrosomal protein 55kDa
up-regulated in colon cancer 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127182.2 → NP_001120654.2  centrosomal protein of 55 kDa

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) results from use of an alternate splice donor site for exon 1.
    Source sequence(s)
    AL356214
    Consensus CDS
    CCDS7428.1
    UniProtKB/Swiss-Prot
    B2RDG8, D3DR37, Q32WF5, Q3MV20, Q53EZ4, Q5VY28, Q6N034, Q96H32, Q9NVS7
    Conserved Domains (1) summary
    COG1196
    Location:21 → 405
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_018131.5 → NP_060601.4  centrosomal protein of 55 kDa

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) results from use of an alternate splice donor site for exon 1.
    Source sequence(s)
    AL356214
    Consensus CDS
    CCDS7428.1
    UniProtKB/Swiss-Prot
    B2RDG8, D3DR37, Q32WF5, Q3MV20, Q53EZ4, Q5VY28, Q6N034, Q96H32, Q9NVS7
    Related
    ENSP00000360540.3, ENST00000371485.8
    Conserved Domains (1) summary
    COG1196
    Location:21 → 405
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    93496612..93529092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016373.2 → XP_016871862.1  centrosomal protein of 55 kDa isoform X1

    Conserved Domains (1) summary
    pfam12180
    Location:2 → 35
    EABR; TSG101 and ALIX binding domain of CEP55

  2. XM_011539919.2 → XP_011538221.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_011538221.1

    Conserved Domains (1) summary
    pfam12180
    Location:2 → 35
    EABR; TSG101 and ALIX binding domain of CEP55

  3. XM_017016372.2 → XP_016871861.1  centrosomal protein of 55 kDa isoform X1

    Conserved Domains (1) summary
    pfam12180
    Location:2 → 35
    EABR; TSG101 and ALIX binding domain of CEP55

  4. XM_047425416.1 → XP_047281372.1  centrosomal protein of 55 kDa isoform X1

  5. XM_011539920.3 → XP_011538222.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_011538222.1

    Conserved Domains (1) summary
    pfam12180
    Location:2 → 35
    EABR; TSG101 and ALIX binding domain of CEP55

  6. XM_011539918.2 → XP_011538220.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_011538220.1

    Conserved Domains (1) summary
    pfam12180
    Location:2 → 35
    EABR; TSG101 and ALIX binding domain of CEP55

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    94376610..94409086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366195.1 → XP_054222170.1  centrosomal protein of 55 kDa isoform X1

  2. XM_054366192.1 → XP_054222167.1  centrosomal protein of 55 kDa isoform X1

  3. XM_054366193.1 → XP_054222168.1  centrosomal protein of 55 kDa isoform X1

  4. XM_054366194.1 → XP_054222169.1  centrosomal protein of 55 kDa isoform X1

  5. XM_054366196.1 → XP_054222171.1  centrosomal protein of 55 kDa isoform X1

  6. XM_054366197.1 → XP_054222172.1  centrosomal protein of 55 kDa isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q53EZ4.3 GenPept UniProtKB/Swiss-Prot:Q53EZ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools