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mtf2 metal response element binding transcription factor 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 550093, updated on 4-Nov-2024

Summary

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Official Symbol
mtf2provided by Xenbase
Official Full Name
metal response element binding transcription factor 2provided by Xenbase
Primary source
Xenbase:XB-GENE-1014957
See related
Ensembl:ENSXETG00000023001 AllianceGenome:Xenbase:XB-GENE-1014957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
m96; pcl2; Xpcl2
Summary
Predicted to enable DNA binding activity; chromatin binding activity; and methylated histone binding activity. Predicted to be involved in negative regulation of gene expression, epigenetic. Predicted to be active in nucleus. Orthologous to human MTF2 (metal response element binding transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mtf2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
15
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (104192932..104228869, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (94019967..94055614, complement)

Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 18 Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene divergent protein kinase domain 1A Neighboring gene provisional ortholog of leucine rich repeat containing 8 VRAC subunit C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC97722

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of gene expression, epigenetic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
metal-response element-binding transcription factor 2
Names
polycomblike 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015829.3 → NP_001015829.2  metal-response element-binding transcription factor 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC090113, CR761989, CR926387, CX347635, CX743530, CX744911, CX923380, DR850829, DR864204
    UniProtKB/TrEMBL
    A0A6I8R2B5, A0A8J0PGL1, Q5FVA6
    Related
    ENSXETP00000079935.2, ENSXETT00000076719.2
    Conserved Domains (4) summary
    smart00333
    Location:45 → 95
    TUDOR; Tudor domain
    cd15578
    Location:104 → 156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:203 → 254
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:545 → 591
    Mtf2_C; Polycomb-like MTF2 factor 2

  2. NM_001017339.3 → NP_001017339.2  metal-response element-binding transcription factor 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC090113, CR761989, CR926387, CX347635, CX478211, CX743530, CX744911, CX923380, DR850828, DR864204
    UniProtKB/TrEMBL
    A0A8J0PJN6, Q28FF9
    Conserved Domains (4) summary
    smart00333
    Location:45 → 95
    TUDOR; Tudor domain
    cd15578
    Location:104 → 156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:203 → 254
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:544 → 590
    Mtf2_C; Polycomb-like MTF2 factor 2

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    104192932..104228869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012961205.3 → XP_012816659.2  metal-response element-binding transcription factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A6I8RSB4, A0A8J0SLN9
    Related
    ENSXETP00000084200.2, ENSXETT00000078484.2
    Conserved Domains (3) summary
    cd15578
    Location:104 → 156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:513 → 560
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd20450
    Location:45 → 97
    Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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