ldlrap1 low density lipoprotein receptor adaptor protein 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: ldlrap1provided by Xenbase
Official Full Name: low density lipoprotein receptor adaptor protein 1provided by Xenbase
Primary source: Xenbase:XB-GENE-954261
See related: Ensembl:ENSXETG00000003693 AllianceGenome:Xenbase:XB-GENE-954261
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: arh; arh1; arh2; xptb; fhcb1; fhcb2; ldlrap1-a; ldlrap1-b
Summary: Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to act upstream of or within cholesterol metabolic process. Predicted to be located in cytoplasm. Predicted to be active in bicellular tight junction and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive hypercholesterolemia. Orthologous to human LDLRAP1 (low density lipoprotein receptor adaptor protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	2	NC_030678.2 (89524762..89539548, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	2	NC_030678.1 (85410915..85426248, complement)

Chromosome 2 - NC_030678.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: low density lipoprotein receptor adapter protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017114.2 → NP_001017114.1 low density lipoprotein receptor adapter protein 1

See identical proteins and their annotated locations for NP_001017114.1

Status: PROVISIONAL

Source sequence(s)

CR761192

UniProtKB/TrEMBL

A9ULP2, F7AG58, Q28GW3

Related

ENSXETP00000007978.3, ENSXETT00000007978.5

Conserved Domains (1) summary

cd13159
Location:43 → 165

PTB_LDLRAP-mammal-like; Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) in mammals and similar proteins Phosphotyrosine-binding (PTB) PH-like fold