mapk12 mitogen-activated protein kinase 12 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: mapk12provided by Xenbase
Official Full Name: mitogen-activated protein kinase 12provided by Xenbase
Primary source: Xenbase:XB-GENE-485782
See related: Ensembl:ENSXETG00000000436 AllianceGenome:Xenbase:XB-GENE-485782
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: erk3; erk6; sapk3; prkm12; sapk-3; p38gamma; Xp38gamma
Summary: Predicted to enable ATP binding activity and MAP kinase activity. Predicted to act upstream of or within MAPK cascade and protein phosphorylation. Orthologous to several human genes including GPCPD1 (glycerophosphocholine phosphodiesterase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	3	NC_030679.2 (71613871..71667303)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	3	NC_030679.1 (62040962..62094108)

Chromosome 3 - NC_030679.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitogen-activated protein kinase 12

Names: SAPK3 protein kinase; Xp38gamma/SAPK3 protein kinase

NP_001017080.1

EC 2.7.11.24

XP_017947594.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017080.2 → NP_001017080.1 mitogen-activated protein kinase 12

See identical proteins and their annotated locations for NP_001017080.1

Status: PROVISIONAL

Source sequence(s)

CR761485

UniProtKB/TrEMBL

A0A6I8S272, A0A6I8SY61, F6UD28, F7A4Q7, Q28G95

Related

ENSXETP00000089002.2, ENSXETT00000096483.2

Conserved Domains (2) summary

cd07880
Location:11 → 353

STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)

smart00220
Location:27 → 311

S_TKc; Serine/Threonine protein kinases, catalytic domain